Zc3h12d zinc finger CCCH type containing 12D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zc3h12dprovided by MGI
Official Full Name: zinc finger CCCH type containing 12Dprovided by MGI
Primary source: MGI:MGI:3045313
See related: Ensembl:ENSMUSG00000039981 AllianceGenome:MGI:3045313
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TFL; D730019B10Rik
Summary: Predicted to enable RNA endonuclease activity and mRNA binding activity. Involved in 3'-UTR-mediated mRNA destabilization. Acts upstream of or within mRNA catabolic process and negative regulation of T cell proliferation. Predicted to be located in P-body and nucleoplasm. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human ZC3H12D (zinc finger CCCH-type containing 12D). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in spleen adult (RPKM 9.8), duodenum adult (RPKM 3.6) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A1; 10 2.44 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (7708087..7746161)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (7832323..7870397)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of ZC3H12D-regulated TLR4-NF-kappaB pathway in LPS-induced pro-inflammatory microglial activation.
Title: The role of ZC3H12D-regulated TLR4-NF-κB pathway in LPS-induced pro-inflammatory microglial activation.
Tfl deletion induces extraordinary Cxcl13 secretion and cachexia in VavP-Bcl2 transgenic mice.
Title: Tfl deletion induces extraordinary Cxcl13 secretion and cachexia in VavP-Bcl2 transgenic mice.
The data indicated that ZC3H12D could suppress both the initial inflammation storm and chronic inflammation by targeting the mRNA of cytokines as well as NF-kappaB and c-fos.
Title: ZC3H12D attenuated inflammation responses by reducing mRNA stability of proinflammatory genes.
TFL (Zc3h12d) may play an important role in attenuating local inflammation by suppressing the infiltration of Th17 cells in the central nervous system during the resolution phase of experimental autoimmune encephalitis.
Title: Posttranscriptional modulation of cytokine production in T cells for the regulation of excessive inflammation by TFL.
Zc3h12d is a novel negative feedback regulator of TLR signaling and macrophage activation and thus may play a role in host immunity and inflammatory diseases.
Title: The putative tumor suppressor Zc3h12d modulates toll-like receptor signaling in macrophages.
MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation.
Title: A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasmic ribonucleoprotein granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable ribonuclease ZC3H12D

Names: transformed follicular lymphoma homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172785.3 → NP_766373.2 probable ribonuclease ZC3H12D

Status: VALIDATED

Source sequence(s)

AC092856, AK052806, BB661745

Consensus CDS

CCDS48496.1

UniProtKB/Swiss-Prot

A4FU74, Q8BIY3

UniProtKB/TrEMBL

E9QNR7

Related

ENSMUSP00000040217.5, ENSMUST00000039484.6

Conserved Domains (3) summary

PHA03247
Location:233 → 516

PHA03247; large tegument protein UL36; Provisional

cd18729
Location:95 → 225

PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins

pfam18039
Location:3 → 44

UBA_6; UBA-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

7708087..7746161

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512724.2 → XP_006512787.1 probable ribonuclease ZC3H12D isoform X1

UniProtKB/Swiss-Prot

A4FU74, Q8BIY3

UniProtKB/TrEMBL

E9QNR7

Conserved Domains (3) summary

PHA03247
Location:233 → 516

PHA03247; large tegument protein UL36; Provisional

cd18729
Location:95 → 225

PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins

pfam18039
Location:3 → 44

UBA_6; UBA-like domain
XM_006512723.4 → XP_006512786.1 probable ribonuclease ZC3H12D isoform X1

UniProtKB/Swiss-Prot

A4FU74, Q8BIY3

UniProtKB/TrEMBL

E9QNR7

Conserved Domains (3) summary

PHA03247
Location:233 → 516

PHA03247; large tegument protein UL36; Provisional

cd18729
Location:95 → 225

PIN_Zc3h12-like; PRORP-like PIN domain of ribonuclease Zc3h12a and related proteins

pfam18039
Location:3 → 44

UBA_6; UBA-like domain