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    Fcrl6 Fc receptor-like 6 [ Mus musculus (house mouse) ]

    Gene ID: 677296, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fcrl6provided by MGI
    Official Full Name
    Fc receptor-like 6provided by MGI
    Primary source
    MGI:MGI:3618339
    See related
    Ensembl:ENSMUSG00000070504 AllianceGenome:MGI:3618339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FcRH6; mIFGP6; moFcRH6
    Summary
    Enables protein phosphatase binding activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Located in external side of plasma membrane. Is expressed in testis and thyroid gland. Orthologous to human FCRL6 (Fc receptor like 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Fcrl6 in Genome Data Viewer
    Location:
    1 H3; 1 80.0 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (172423081..172445889, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172595514..172618322, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene V-set and immunoglobulin domain containing 8 Neighboring gene SLAM family member 8 Neighboring gene STARR-positive B cell enhancer mm9_chr1:174563024-174563325 Neighboring gene dual specificity phosphatase 23 Neighboring gene predicted gene, 35601 Neighboring gene STARR-seq mESC enhancer starr_03070

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fc Receptor-Like 6 (FCRL6) Discloses Progenitor B Cell Heterogeneity That Correlates With Pre-BCR Dependent and Independent Pathways of Natural Antibody Selection. Honjo K, et al. Front Immunol, 2020. PMID 32117244, Free PMC Article
    2. Species-specific evolution of the FcR family in endothermic vertebrates. Fayngerts SA, et al. Immunogenetics, 2007 Jun. PMID 17356879
    3. New nomenclature for Fc receptor-like molecules. Maltais LJ, et al. Nat Immunol, 2006 May. PMID 16622424
    4. FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Wilson TJ, et al. Blood, 2007 May 1. PMID 17213291
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fc Receptor-Like 6 (FCRL6) Discloses Progenitor B Cell Heterogeneity That Correlates With Pre-BCR Dependent and Independent Pathways of Natural Antibody Selection.
      Title: Fc Receptor-Like 6 (FCRL6) Discloses Progenitor B Cell Heterogeneity That Correlates With Pre-BCR Dependent and Independent Pathways of Natural Antibody Selection.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class II protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Fc receptor-like protein 6
    Names
    cell surface glycoprotein gp42
    fcR-like protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164725.1 → NP_001158197.1  Fc receptor-like protein 6 precursor

      See identical proteins and their annotated locations for NP_001158197.1

      Status: VALIDATED

      Source sequence(s)
      AC131177
      Consensus CDS
      CCDS48448.1
      UniProtKB/Swiss-Prot
      A1YIY0, E9QM04
      Related
      ENSMUSP00000091861.5, ENSMUST00000094303.6
      Conserved Domains (2) summary
      pfam13895
      Location:22 → 106
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:114 → 187
      Ig_3; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      172423081..172445889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496971.3 → XP_006497034.1  Fc receptor-like protein 6 isoform X3

      See identical proteins and their annotated locations for XP_006497034.1

      Conserved Domains (2) summary
      pfam13895
      Location:22 → 100
      Ig_2; Immunoglobulin domain
      pfam17736
      Location:128 → 196
      Ig_C17orf99; C17orf99 Ig domain

    2. XM_011238861.2 → XP_011237163.1  Fc receptor-like protein 6 isoform X2

      Conserved Domains (2) summary
      pfam13895
      Location:50 → 133
      Ig_2; Immunoglobulin domain
      pfam17736
      Location:161 → 229
      Ig_C17orf99; C17orf99 Ig domain

    3. XM_011238860.2 → XP_011237162.1  Fc receptor-like protein 6 isoform X1

      Conserved Domains (2) summary
      pfam13895
      Location:50 → 133
      Ig_2; Immunoglobulin domain
      pfam17736
      Location:161 → 229
      Ig_C17orf99; C17orf99 Ig domain

    4. XM_006496972.3 → XP_006497035.1  Fc receptor-like protein 6 isoform X3

      See identical proteins and their annotated locations for XP_006497035.1

      Conserved Domains (2) summary
      pfam13895
      Location:22 → 100
      Ig_2; Immunoglobulin domain
      pfam17736
      Location:128 → 196
      Ig_C17orf99; C17orf99 Ig domain

    5. XM_011238862.2 → XP_011237164.1  Fc receptor-like protein 6 isoform X3

      See identical proteins and their annotated locations for XP_011237164.1

      Conserved Domains (2) summary
      pfam13895
      Location:22 → 100
      Ig_2; Immunoglobulin domain
      pfam17736
      Location:128 → 196
      Ig_C17orf99; C17orf99 Ig domain

    6. XM_030242468.1 → XP_030098328.1  Fc receptor-like protein 6 isoform X4

      Conserved Domains (1) summary
      pfam13895
      Location:50 → 133
      Ig_2; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1YIY0.2 GenPept UniProtKB/Swiss-Prot:A1YIY0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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