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    Endog endonuclease G [ Mus musculus (house mouse) ]

    Gene ID: 13804, updated on 27-Nov-2024

    Summary

    Official Symbol
    Endogprovided by MGI
    Official Full Name
    endonuclease Gprovided by MGI
    Primary source
    MGI:MGI:1261433
    See related
    Ensembl:ENSMUSG00000015337 AllianceGenome:MGI:1261433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables DNA endonuclease activity; magnesium ion binding activity; and protein homodimerization activity. Involved in negative regulation of TOR signaling and positive regulation of autophagy. Acts upstream of or within several processes, including apoptotic DNA fragmentation; in utero embryonic development; and response to tumor necrosis factor. Located in mitochondrion. Is expressed in several structures, including brown fat; gut; liver; male reproductive gland or organ; and respiratory system. Orthologous to human ENDOG (endonuclease G). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 57.2), duodenum adult (RPKM 56.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Endog in Genome Data Viewer
    Location:
    2 B; 2 21.29 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30061525..30064057)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30171408..30174069)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 (zinc transporter), member 1, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7803 Neighboring gene predicted gene, 31080 Neighboring gene STARR-positive B cell enhancer ABC_E2609 Neighboring gene SPOUT domain containing methyltransferase 1 Neighboring gene kynurenine aminotransferase 1 Neighboring gene predicted gene, 31201 Neighboring gene STARR-seq mESC enhancer starr_04089 Neighboring gene STARR-seq mESC enhancer starr_04090 Neighboring gene RIKEN cDNA 1700084E18 gene Neighboring gene STARR-positive B cell enhancer ABC_E7804

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA endonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA nuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in DNA catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within apoptotic DNA fragmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial DNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial DNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic DNA fragmentation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic DNA fragmentation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hydrogen peroxide-mediated programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of hydrogen peroxide-mediated programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to tumor necrosis factor IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    endonuclease G, mitochondrial
    Names
    endo G
    NP_031957.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007931.2NP_031957.1  endonuclease G, mitochondrial precursor

      See identical proteins and their annotated locations for NP_031957.1

      Status: VALIDATED

      Source sequence(s)
      AL845258
      Consensus CDS
      CCDS15872.1
      UniProtKB/Swiss-Prot
      O08600
      UniProtKB/TrEMBL
      Q3UN47
      Related
      ENSMUSP00000015481.6, ENSMUST00000015481.6
      Conserved Domains (2) summary
      smart00477
      Location:75281
      NUC; DNA/RNA non-specific endonuclease
      COG1864
      Location:29278
      NUC1; DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]

    RNA

    1. NR_184725.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845258
    2. NR_184726.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845258
    3. NR_184727.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845258

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30061525..30064057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)