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    Slc47a1 solute carrier family 47, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 67473, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc47a1provided by MGI
    Official Full Name
    solute carrier family 47, member 1provided by MGI
    Primary source
    MGI:MGI:1914723
    See related
    Ensembl:ENSMUSG00000010122 AllianceGenome:MGI:1914723
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MATE1; mMATE1; 1300013J15Rik
    Summary
    Enables polyspecific organic cation:proton antiporter activity. Involved in monoatomic cation transmembrane transport and xenobiotic transmembrane transport. Located in plasma membrane. Is expressed in several structures, including liver; lung; metanephros; nervous system; and spleen. Orthologous to several human genes including SLC47A1 (solute carrier family 47 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 97.2), liver adult (RPKM 32.0) and 3 other tissues See more
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    Genomic context

    See Slc47a1 in Genome Data Viewer
    Location:
    11 B2; 11 37.96 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61234226..61269668, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61343400..61378842, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase family 3, subfamily A2 Neighboring gene STARR-positive B cell enhancer ABC_E6993 Neighboring gene STARR-seq mESC enhancer starr_29673 Neighboring gene STARR-seq mESC enhancer starr_29674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:61123776-61123977 Neighboring gene solute carrier family 47, member 2 Neighboring gene predicted gene, 25929 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 12 Neighboring gene STARR-seq mESC enhancer starr_29676 Neighboring gene predicted gene, 42081 Neighboring gene STARR-positive B cell enhancer ABC_E6994 Neighboring gene nuclear encoded tRNA trytophan 5 (anticodon CCA)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-arginine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables organic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables organic cation transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables polyspecific organic cation:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables polyspecific organic cation:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables putrescine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables putrescine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables thiamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thiamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables xenobiotic transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in L-arginine import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-arginine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic cation transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monoatomic cation transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoatomic cation transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in organic cation transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in putrescine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in thiamine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    multidrug and toxin extrusion protein 1
    Names
    MATE-1
    mMATE-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026183.5NP_080459.2  multidrug and toxin extrusion protein 1

      See identical proteins and their annotated locations for NP_080459.2

      Status: VALIDATED

      Source sequence(s)
      AK009038, BB556514, BB661673, BY006577
      Consensus CDS
      CCDS24811.2
      UniProtKB/Swiss-Prot
      Q5SS45, Q8K0H1, Q9CQ64
      Related
      ENSMUSP00000010267.4, ENSMUST00000010267.10
      Conserved Domains (1) summary
      cd13132
      Location:34468
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      61234226..61269668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249188.3XP_011247490.1  multidrug and toxin extrusion protein 1 isoform X2

      Conserved Domains (1) summary
      cd13132
      Location:1418
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    2. XM_006533993.2XP_006534056.1  multidrug and toxin extrusion protein 1 isoform X1

      Conserved Domains (1) summary
      cd13132
      Location:70492
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    3. XM_036156909.1XP_036012802.1  multidrug and toxin extrusion protein 1 isoform X4

      Conserved Domains (1) summary
      cd13132
      Location:22308
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    4. XM_036156910.1XP_036012803.1  multidrug and toxin extrusion protein 1 isoform X4

      Conserved Domains (1) summary
      cd13132
      Location:22308
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    5. XM_011249189.4XP_011247491.1  multidrug and toxin extrusion protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011247491.1

      UniProtKB/Swiss-Prot
      Q8K0H1
      Conserved Domains (1) summary
      cd13132
      Location:40326
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
    6. XM_006533995.4XP_006534058.1  multidrug and toxin extrusion protein 1 isoform X5

      Conserved Domains (1) summary
      cd13132
      Location:1280
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    RNA

    1. XR_003949493.1 RNA Sequence