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    ZNF425 zinc finger protein 425 [ Homo sapiens (human) ]

    Gene ID: 155054, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF425provided by HGNC
    Official Full Name
    zinc finger protein 425provided by HGNC
    Primary source
    HGNC:HGNC:20690
    See related
    Ensembl:ENSG00000204947 MIM:619507; AllianceGenome:HGNC:20690
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 1.8), brain (RPKM 1.7) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF425 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149102784..149126324, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150284907..150308127, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148799876..148823416, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148762397-148763279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148768421-148769413 Neighboring gene zinc finger protein 786 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18746 Neighboring gene MPRA-validated peak6836 silencer Neighboring gene MPRA-validated peak6837 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:148821330-148821830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:148821831-148822331 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148822579-148823130 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148823131-148823682 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26808 Neighboring gene RNA, 7SL, cytoplasmic 521, pseudogene Neighboring gene zinc finger protein 398 Neighboring gene uncharacterized LOC107986856 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:148842175-148842748 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148842749-148843322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148843323-148843896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26809 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148844471-148845044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148853225-148853792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148853793-148854358 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148854359-148854926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26811 Neighboring gene centrosomal protein 83kDa pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel human KRAB-related zinc finger gene ZNF425 inhibits mitogen-activated protein kinase signaling pathway. Wang Y, et al. BMB Rep, 2011 Jan. PMID 21266108
    2. Human chromosome 7: DNA sequence and biology. Scherer SW, et al. Science, 2003 May 2. PMID 12690205, Free PMC Article
    3. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: ZNF786

    Homology

    Clone Names

    • MGC150568

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 425

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001661.3 → NP_001001661.1  zinc finger protein 425

      See identical proteins and their annotated locations for NP_001001661.1

      Status: VALIDATED

      Source sequence(s)
      AC073422, AY621067
      Consensus CDS
      CCDS34773.1
      UniProtKB/Swiss-Prot
      B3KPM1, Q08AG3, Q6IV72
      UniProtKB/TrEMBL
      A0A090N7U3
      Related
      ENSP00000367300.2, ENST00000378061.7
      Conserved Domains (6) summary
      smart00349
      Location:9 → 64
      KRAB; krueppel associated box
      COG5048
      Location:355 → 731
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:500 → 520
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:358 → 380
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:9 → 48
      KRAB; KRAB box
      pfam13465
      Location:401 → 423
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      149102784..149126324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      150284907..150308127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IV72.1 GenPept UniProtKB/Swiss-Prot:Q6IV72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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