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    FGF7 fibroblast growth factor 7 [ Homo sapiens (human) ]

    Gene ID: 2252, updated on 4-Jan-2025

    Summary

    Official Symbol
    FGF7provided by HGNC
    Official Full Name
    fibroblast growth factor 7provided by HGNC
    Primary source
    HGNC:HGNC:3685
    See related
    Ensembl:ENSG00000140285 MIM:148180; AllianceGenome:HGNC:3685
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KGF; HBGF-7
    Summary
    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in gall bladder (RPKM 32.8), urinary bladder (RPKM 19.9) and 15 other tissues See more
    Orthologs
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    Genomic context

    See FGF7 in Genome Data Viewer
    Location:
    15q21.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (49423242..49488775)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (47231591..47297131)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (49715439..49780972)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene galactokinase 2 Neighboring gene MPRA-validated peak2332 silencer Neighboring gene RNA, 7SL, cytoplasmic 307, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:49523773-49524444 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:49524445-49525115 Neighboring gene Sharpr-MPRA regulatory region 5673 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:49557847-49559046 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:49646702-49647347 Neighboring gene family with sequence similarity 227 member B Neighboring gene signal peptide peptidase like 2A pseudogene Neighboring gene OCT4 hESC enhancer GRCh37_chr15:49664491-49665044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:49671731-49672256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:49672257-49672781 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:49688382-49688895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9387 Neighboring gene uncharacterized LOC105370811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9388 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:49917323-49918522 Neighboring gene DTW domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (16 hits/1248 screens)

    EBI GWAS Catalog

    Description
    A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
    EBI GWAS Catalog
    Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of fibroblast growth factor 7 (FGF7) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of fibroblast growth factor 7 (FGF7; KGF: keratinocyte growth factor) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chemoattractant activity PubMed 
    enables growth factor activity  
    enables heparin binding  
    enables protein binding PubMed 
    enables type 2 fibroblast growth factor receptor binding  
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization PubMed 
    involved_in branching involved in salivary gland morphogenesis  
    involved_in endothelial cell proliferation  
    involved_in epidermis development PubMed 
    involved_in fibroblast growth factor receptor signaling pathway  
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway PubMed 
    involved_in hair follicle morphogenesis  
    involved_in lung development  
    involved_in mesenchymal cell proliferation PubMed 
    involved_in myoblast proliferation  
    involved_in neurogenesis  
    involved_in positive chemotaxis PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of cell division  
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of epithelial cell proliferation  
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation PubMed 
    involved_in positive regulation of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis PubMed 
    involved_in positive regulation of keratinocyte migration PubMed 
    involved_in positive regulation of keratinocyte proliferation PubMed 
    involved_in positive regulation of myoblast proliferation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation PubMed 
    involved_in protein localization to cell surface PubMed 
    involved_in regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  
    involved_in regulation of cell migration  
    involved_in regulation of synapse maturation  
    involved_in response to wounding PubMed 
    involved_in secretion by lung epithelial cell involved in lung growth PubMed 
    involved_in signal transduction PubMed 
    Items 1 - 25 of 32
    Component Evidence Code Pubs
    located_in GABA-ergic synapse  
    located_in Golgi apparatus  
    is_active_in cytoplasm  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in postsynapse  

    General protein information

    Preferred Names
    fibroblast growth factor 7
    Names
    FGF-7
    heparin-binding growth factor 7
    keratinocyte growth factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029159.1 RefSeqGene

      Range
      5065..70598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002009.4 → NP_002000.1  fibroblast growth factor 7 precursor

      See identical proteins and their annotated locations for NP_002000.1

      Status: REVIEWED

      Source sequence(s)
      AC025919, DB206350, M60828
      Consensus CDS
      CCDS10131.1
      UniProtKB/Swiss-Prot
      H0YNY5, P21781, Q6FGV5, Q96FG5
      UniProtKB/TrEMBL
      A0A7U3JVY2
      Related
      ENSP00000267843.4, ENST00000267843.9
      Conserved Domains (1) summary
      pfam00167
      Location:65 → 189
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      49423242..49488775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      47231591..47297131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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