U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dhrs4 dehydrogenase/reductase 4 [ Mus musculus (house mouse) ]

    Gene ID: 28200, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dhrs4provided by MGI
    Official Full Name
    dehydrogenase/reductase 4provided by MGI
    Primary source
    MGI:MGI:90169
    See related
    Ensembl:ENSMUSG00000022210 AllianceGenome:MGI:90169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CR; RRD; NDRD; PHCR; PSCD; mouNRDR; D14Ucla2
    Summary
    Enables retinal dehydrogenase activity. Acts upstream of or within retinal metabolic process. Located in mitochondrion and peroxisome. Orthologous to several human genes including DHRS4 (dehydrogenase/reductase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 28.9), liver E18 (RPKM 24.8) and 28 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dhrs4 in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55715880..55727797)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55478741..55490340)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52145 Neighboring gene STARR-positive B cell enhancer ABC_E5438 Neighboring gene STARR-seq mESC enhancer starr_36769 Neighboring gene predicted gene, 41158 Neighboring gene capping protein regulator and myosin 1 linker 3 Neighboring gene copine VI

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-keto sterol reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables alcohol dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables all-trans-retinol dehydrogenase (NADP+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables carbonyl reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carbonyl reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables carbonyl reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
    Inferred from Sequence Orthology
    more info
     
    enables retinal dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ketone metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in retinal metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within retinal metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in steroid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dehydrogenase/reductase SDR family member 4
    Names
    NADPH-dependent carbonyl reductase
    NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase
    NADPH-dependent retinol dehydrogenase/reductase
    dehydrogenase/reductase (SDR family) member 4
    peroxisomal short-chain alcohol dehydrogenase
    short chain dehydrogenase/reductase family 25C member 2
    NP_001033027.2
    NP_109611.1
    XP_030103712.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037938.2NP_001033027.2  dehydrogenase/reductase SDR family member 4 isoform 1

      See identical proteins and their annotated locations for NP_001033027.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC159002, AK146988, BQ032668, BY291911
      Consensus CDS
      CCDS27111.1
      UniProtKB/Swiss-Prot
      G3X8V7, Q99LB2, Q9EQU4
      UniProtKB/TrEMBL
      Q3UIB5
      Related
      ENSMUSP00000022821.7, ENSMUST00000022821.8
      Conserved Domains (2) summary
      cd08936
      Location:24279
      CR_SDR_c; Porcine peroxisomal carbonyl reductase like, classical (c) SDR
      PRK07231
      Location:31274
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional
    2. NM_030686.2NP_109611.1  dehydrogenase/reductase SDR family member 4 isoform 2

      See identical proteins and their annotated locations for NP_109611.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC159002, AK018788, AW125533, BY291911
      Consensus CDS
      CCDS88668.1
      UniProtKB/TrEMBL
      Q9D2U3
      Related
      ENSMUSP00000154481.2, ENSMUST00000226168.2
      Conserved Domains (1) summary
      cl21454
      Location:24178
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55715880..55727797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247852.2XP_030103712.1  dehydrogenase/reductase SDR family member 4 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:24137
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins