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    KIF14 kinesin family member 14 [ Homo sapiens (human) ]

    Gene ID: 9928, updated on 5-Jan-2025

    Summary

    Official Symbol
    KIF14provided by HGNC
    Official Full Name
    kinesin family member 14provided by HGNC
    Primary source
    HGNC:HGNC:19181
    See related
    Ensembl:ENSG00000118193 MIM:611279; AllianceGenome:HGNC:19181
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MKS12; MCPH20
    Summary
    This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
    Expression
    Broad expression in bone marrow (RPKM 2.3), lymph node (RPKM 1.7) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See KIF14 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (200551497..200620751, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (199808434..199877845, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (200520625..200589879, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900414 Neighboring gene uncharacterized LOC124904480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1671 Neighboring gene uncharacterized LOC107985459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1673 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200589147-200589648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1674 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200607918-200608633 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:200608609-200609808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1675 Neighboring gene DEAD-box helicase 59 Neighboring gene DDX59 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2302 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1677 Neighboring gene MPRA-validated peak646 silencer Neighboring gene calmodulin regulated spectrin associated protein family member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200735945-200736445

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA0042, MGC142302

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables PDZ domain binding PubMed 
    enables microtubule binding  
    enables microtubule binding  
    enables microtubule motor activity  
    enables plus-end-directed microtubule motor activity  
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    enables tubulin binding  
    Items 1 - 25 of 31
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process PubMed 
    involved_in activation of protein kinase activity PubMed 
    involved_in cell division  
    involved_in cell proliferation in forebrain  
    involved_in cerebellar Purkinje cell layer structural organization  
    involved_in cerebellar cortex development  
    involved_in cerebellar granular layer structural organization  
    involved_in cerebral cortex development  
    acts_upstream_of_or_within establishment of protein localization PubMed 
    involved_in hippocampus development  
    NOT involved_in microtubule depolymerization  
    involved_in microtubule-based movement  
    involved_in mitotic metaphase chromosome alignment PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of integrin activation PubMed 
    involved_in negative regulation of neuron apoptotic process  
    involved_in olfactory bulb development  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cytokinesis PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle PubMed 
    involved_in regulation of G2/M transition of mitotic cell cycle PubMed 
    acts_upstream_of_or_within regulation of Rap protein signal transduction PubMed 
    acts_upstream_of_or_within regulation of cell adhesion PubMed 
    involved_in regulation of cell growth PubMed 
    involved_in regulation of cell maturation  
    acts_upstream_of_or_within regulation of cell migration PubMed 
    involved_in regulation of myelination  
    involved_in regulation of neuron apoptotic process  
    acts_upstream_of_or_within substrate adhesion-dependent cell spreading PubMed 
    Items 1 - 25 of 31
    Component Evidence Code Pubs
    located_in Flemming body  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    part_of kinesin complex  
    located_in membrane PubMed 
    is_active_in microtubule  
    located_in microtubule PubMed 
    located_in midbody PubMed 
    located_in nucleus  
    colocalizes_with plasma membrane PubMed 
    located_in spindle midzone PubMed 

    General protein information

    Preferred Names
    kinesin-like protein KIF14
    Names
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042074.1 RefSeqGene

      Range
      4984..74235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001305792.1 → NP_001292721.1  kinesin-like protein KIF14 isoform 2

      See identical proteins and their annotated locations for NP_001292721.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AL445483, BC098582, BC113742, BC144068, BE644769, BQ425495, CN307042, CR748178, D26361
      UniProtKB/Swiss-Prot
      Q15058
      Conserved Domains (5) summary
      smart00129
      Location:1 → 217
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:312 → 409
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl22853
      Location:1 → 217
      Motor_domain; Myosin and Kinesin motor domain
      pfam11068
      Location:471 → 531
      YlqD; YlqD protein
      pfam16183
      Location:214 → 332
      Kinesin_assoc; Kinesin-associated
    2. NM_014875.3 → NP_055690.1  kinesin-like protein KIF14 isoform 1

      See identical proteins and their annotated locations for NP_055690.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL445483, BC098582, D26361
      Consensus CDS
      CCDS30963.1
      UniProtKB/Swiss-Prot
      Q14CI8, Q15058, Q4G0A5, Q5T1W3
      Related
      ENSP00000356319.4, ENST00000367350.5
      Conserved Domains (5) summary
      smart00129
      Location:358 → 708
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:803 → 900
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:357 → 708
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:962 → 1022
      YlqD; YlqD protein
      pfam16183
      Location:705 → 823
      Kinesin_assoc; Kinesin-associated

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      200551497..200620751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436198.1 → XP_047292154.1  kinesin-like protein KIF14 isoform X5

    2. XM_047436190.1 → XP_047292146.1  kinesin-like protein KIF14 isoform X2

    3. XM_011510232.3 → XP_011508534.1  kinesin-like protein KIF14 isoform X1

      See identical proteins and their annotated locations for XP_011508534.1

      UniProtKB/Swiss-Prot
      Q14CI8, Q15058, Q4G0A5, Q5T1W3
      Related
      ENSP00000483069.1, ENST00000614960.4
      Conserved Domains (5) summary
      smart00129
      Location:358 → 708
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:803 → 900
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:357 → 708
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:962 → 1022
      YlqD; YlqD protein
      pfam16183
      Location:705 → 823
      Kinesin_assoc; Kinesin-associated
    4. XM_017003007.2 → XP_016858496.1  kinesin-like protein KIF14 isoform X7

      Conserved Domains (3) summary
      cd00060
      Location:614 → 711
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      TIGR02168
      Location:733 → 884
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01365
      Location:168 → 519
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    5. XM_047436199.1 → XP_047292155.1  kinesin-like protein KIF14 isoform X6

    6. XM_047436195.1 → XP_047292151.1  kinesin-like protein KIF14 isoform X4

    7. XM_017003006.2 → XP_016858495.1  kinesin-like protein KIF14 isoform X3

    8. XM_011510235.3 → XP_011508537.1  kinesin-like protein KIF14 isoform X5

      Conserved Domains (5) summary
      smart00129
      Location:234 → 584
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:679 → 776
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:233 → 584
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:838 → 898
      YlqD; YlqD protein
      pfam16183
      Location:581 → 699
      Kinesin_assoc; Kinesin-associated
    9. XM_011510233.3 → XP_011508535.1  kinesin-like protein KIF14 isoform X2

      Conserved Domains (5) summary
      smart00129
      Location:330 → 680
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:775 → 872
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:329 → 680
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:934 → 994
      YlqD; YlqD protein
      pfam16183
      Location:677 → 795
      Kinesin_assoc; Kinesin-associated
    10. XM_047436181.1 → XP_047292137.1  kinesin-like protein KIF14 isoform X2

    11. XM_011510231.3 → XP_011508533.1  kinesin-like protein KIF14 isoform X1

      See identical proteins and their annotated locations for XP_011508533.1

      UniProtKB/Swiss-Prot
      Q14CI8, Q15058, Q4G0A5, Q5T1W3
      Conserved Domains (5) summary
      smart00129
      Location:358 → 708
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:803 → 900
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:357 → 708
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam11068
      Location:962 → 1022
      YlqD; YlqD protein
      pfam16183
      Location:705 → 823
      Kinesin_assoc; Kinesin-associated
    12. XM_047436197.1 → XP_047292153.1  kinesin-like protein KIF14 isoform X5

    13. XM_047436184.1 → XP_047292140.1  kinesin-like protein KIF14 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      199808434..199877845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339956.1 → XP_054195931.1  kinesin-like protein KIF14 isoform X1

      UniProtKB/TrEMBL
      A0A384P5W4
    2. XM_054339960.1 → XP_054195935.1  kinesin-like protein KIF14 isoform X2

    3. XM_054339964.1 → XP_054195939.1  kinesin-like protein KIF14 isoform X5

    4. XM_054339967.1 → XP_054195942.1  kinesin-like protein KIF14 isoform X7

    5. XM_054339966.1 → XP_054195941.1  kinesin-like protein KIF14 isoform X6

    6. XM_054339962.1 → XP_054195937.1  kinesin-like protein KIF14 isoform X4

    7. XM_054339961.1 → XP_054195936.1  kinesin-like protein KIF14 isoform X3

    8. XM_054339963.1 → XP_054195938.1  kinesin-like protein KIF14 isoform X5

    9. XM_054339957.1 → XP_054195932.1  kinesin-like protein KIF14 isoform X2

    10. XM_054339958.1 → XP_054195933.1  kinesin-like protein KIF14 isoform X2

    11. XM_054339955.1 → XP_054195930.1  kinesin-like protein KIF14 isoform X1

      UniProtKB/TrEMBL
      A0A384P5W4
    12. XM_054339965.1 → XP_054195940.1  kinesin-like protein KIF14 isoform X5

    13. XM_054339959.1 → XP_054195934.1  kinesin-like protein KIF14 isoform X2

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