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    Ap3b2 adaptor-related protein complex 3, beta 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 11775, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ap3b2provided by MGI
    Official Full Name
    adaptor-related protein complex 3, beta 2 subunitprovided by MGI
    Primary source
    MGI:MGI:1100869
    See related
    Ensembl:ENSMUSG00000062444 AllianceGenome:MGI:1100869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Naptb; beta3B; [b]-NAP; beta-NAP
    Summary
    Involved in anterograde synaptic vesicle transport and synaptic vesicle endocytosis. Is active in presynapse. Is expressed in adrenal gland; gut; nervous system; sensory organ; and testis. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 48. Orthologous to human AP3B2 (adaptor related protein complex 3 subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 43.3), whole brain E14.5 (RPKM 36.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ap3b2 in Genome Data Viewer
    Location:
    7 D3; 7 45.71 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (81110147..81143722, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (81460399..81493997, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cytoplasmic polyadenylation element binding protein 1 Neighboring gene small nuclear ribonucleoprotein 48 (U11/U12) pseudogene Neighboring gene ribosomal protein L7A, pseudogene 9 Neighboring gene STARR-seq mESC enhancer starr_19364 Neighboring gene cDNA sequence BC048679 Neighboring gene predicted gene, 45991

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Spontaneous (2) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC36656

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of AP-3 adaptor complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    AP-3 complex subunit beta-2
    Names
    AP-3 complex beta-2 subunit
    adapter-related protein complex 3 subunit beta-2
    adaptor protein complex AP-3 beta-2 subunit
    adaptor protein complex AP-3 subunit beta-2
    adaptor-related protein complex 3 subunit beta-2
    adaptor-related protein complex AP-3, beta 2 subunit
    beta-3B-adaptin
    beta3B-adaptin
    clathrin assembly protein complex 3 beta-2 large chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021492.3NP_067467.2  AP-3 complex subunit beta-2

      See identical proteins and their annotated locations for NP_067467.2

      Status: VALIDATED

      Source sequence(s)
      AY528675, CJ064603
      Consensus CDS
      CCDS21403.1
      UniProtKB/Swiss-Prot
      B2RTK2, Q3UYP8, Q6QR53, Q8R1E5, Q9JME5
      UniProtKB/TrEMBL
      A0A571BEW4
      Related
      ENSMUSP00000080739.8, ENSMUST00000082090.15
      Conserved Domains (4) summary
      pfam01602
      Location:34590
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:123262
      Cnd1; non-SMC mitotic condensation complex subunit 1
      pfam14796
      Location:804947
      AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal
      sd00044
      Location:111139
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      81110147..81143722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540571.5XP_006540634.1  AP-3 complex subunit beta-2 isoform X1

      UniProtKB/TrEMBL
      A0A571BES1, A0A571BEW4
      Related
      ENSMUSP00000158658.2, ENSMUST00000238438.2
      Conserved Domains (3) summary
      sd00044
      Location:111139
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:34590
      Adaptin_N; Adaptin N terminal region
      pfam14796
      Location:823966
      AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_146192.1: Suppressed sequence

      Description
      NM_146192.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.