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    Pou2f2 POU domain, class 2, transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 18987, updated on 3-Dec-2024

    Summary

    Official Symbol
    Pou2f2provided by MGI
    Official Full Name
    POU domain, class 2, transcription factor 2provided by MGI
    Primary source
    MGI:MGI:101897
    See related
    Ensembl:ENSMUSG00000008496 AllianceGenome:MGI:101897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Otf2; Oct-2; Oct2a; Oct2b; Oct2c; Oct2d; Otf-2
    Summary
    Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and spermidine transmembrane transporter activity. Involved in cellular response to virus; positive regulation of macromolecule biosynthetic process; and spermidine transport. Acts upstream of or within cell maturation; mature B cell differentiation; and positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; nervous system; sensory organ; and thymus. Orthologous to human POU2F2 (POU class 2 homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 14.3), whole brain E14.5 (RPKM 4.2) and 11 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pou2f2 in Genome Data Viewer
    Location:
    7 A3; 7 13.73 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24790111..24879292, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25087350..25180797, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ATPase, Na+/K+ transporting, alpha 3 polypeptide Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25785259-25785485 Neighboring gene microRNA 7047 Neighboring gene glutamate receptor, ionotropic, kainate 5 (gamma 2) Neighboring gene STARR-seq mESC enhancer starr_18288 Neighboring gene zinc finger protein 574 Neighboring gene STARR-positive B cell enhancer ABC_E3704 Neighboring gene microRNA 6537 Neighboring gene STARR-seq mESC enhancer starr_18291 Neighboring gene STARR-positive B cell enhancer ABC_E2225 Neighboring gene STARR-positive B cell enhancer ABC_E6522 Neighboring gene STARR-positive B cell enhancer ABC_E3705 Neighboring gene RIKEN cDNA D930028M14 gene Neighboring gene STARR-seq mESC enhancer starr_18292 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25990365-25990647 Neighboring gene STARR-seq mESC enhancer starr_18294 Neighboring gene STARR-positive B cell enhancer ABC_E868 Neighboring gene STARR-positive B cell enhancer ABC_E1724 Neighboring gene RIKEN cDNA 9130221H12 gene Neighboring gene death effector domain-containing DNA binding protein 2 Neighboring gene microRNA 7048 Neighboring gene zinc finger protein 526 Neighboring gene glycogen synthase kinase 3 alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC124154, MGC124155, MGC124156

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    POU domain, class 2, transcription factor 2
    Names
    lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
    octamer-binding protein 2
    octamer-binding transcription factor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163554.2NP_001157026.1  POU domain, class 2, transcription factor 2 isoform 4

      See identical proteins and their annotated locations for NP_001157026.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an additional exon in the 3' coding region, as compared to variant 1. The resulting isoform (4) has a longer and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC120393
      Consensus CDS
      CCDS52144.1
      UniProtKB/Swiss-Prot
      Q00196
      Related
      ENSMUSP00000104056.4, ENSMUST00000108418.11
      Conserved Domains (2) summary
      smart00352
      Location:179253
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:284337
      Homeobox; Homeobox domain
    2. NM_001163555.2NP_001157027.1  POU domain, class 2, transcription factor 2 isoform 3

      See identical proteins and their annotated locations for NP_001157027.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional segment in the coding region, as compared to variant 1. The resulting isoform (3) is longer and has the same N- and C-termini, as compared to isoform 1.
      Source sequence(s)
      AC120393
      Consensus CDS
      CCDS52145.1
      UniProtKB/TrEMBL
      H3BKB7
      Related
      ENSMUSP00000104055.3, ENSMUST00000108417.10
      Conserved Domains (2) summary
      smart00352
      Location:201275
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:306360
      Homeobox; Homeobox domain
    3. NM_001163556.2NP_001157028.1  POU domain, class 2, transcription factor 2 isoform 1

      See identical proteins and their annotated locations for NP_001157028.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC120393
      Consensus CDS
      CCDS52143.1
      UniProtKB/Swiss-Prot
      Q00196, Q00197, Q00198, Q00199, Q00200, Q00201, Q05882, Q3KR47, Q3U127, Q5XML1, Q5XML2, Q61995, Q61996, Q64245
      UniProtKB/TrEMBL
      H3BKB7
      Related
      ENSMUSP00000135075.2, ENSMUST00000175774.9
      Conserved Domains (2) summary
      smart00352
      Location:179253
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:284338
      Homeobox; Homeobox domain
    4. NM_001417132.1NP_001404061.1  POU domain, class 2, transcription factor 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC120393
    5. NM_001417133.1NP_001404062.1  POU domain, class 2, transcription factor 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC120393
    6. NM_001417134.1NP_001404063.1  POU domain, class 2, transcription factor 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC120393
    7. NM_001417135.1NP_001404064.1  POU domain, class 2, transcription factor 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC120393
    8. NM_001417136.1NP_001404065.1  POU domain, class 2, transcription factor 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC120393
    9. NM_001417137.1NP_001404066.1  POU domain, class 2, transcription factor 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC120393
    10. NM_001417138.1NP_001404067.1  POU domain, class 2, transcription factor 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC120393
    11. NM_001417139.1NP_001404068.1  POU domain, class 2, transcription factor 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC120393
    12. NM_001417140.1NP_001404069.1  POU domain, class 2, transcription factor 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC120393
      UniProtKB/TrEMBL
      H3BKB7
      Related
      ENSMUSP00000104054.3, ENSMUST00000108416.10
    13. NM_001417141.1NP_001404070.1  POU domain, class 2, transcription factor 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC120393
    14. NM_011138.3NP_035268.2  POU domain, class 2, transcription factor 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional segment in the coding region, as compared to variant 1. The resulting isoform (2) is longer and has the same N- and C-termini, as compared to isoform 1.
      Source sequence(s)
      AC120393
      Consensus CDS
      CCDS39834.1
      UniProtKB/TrEMBL
      H3BKB7
      Related
      ENSMUSP00000104053.3, ENSMUST00000108415.10
      Conserved Domains (3) summary
      smart00352
      Location:195269
      POU; Found in Pit-Oct-Unc transcription factors
      pfam00046
      Location:300354
      Homeobox; Homeobox domain
      pfam09770
      Location:116193
      PAT1; Topoisomerase II-associated protein PAT1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      24790111..24879292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)