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    Cela2a chymotrypsin-like elastase family, member 2A [ Mus musculus (house mouse) ]

    Gene ID: 13706, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cela2aprovided by MGI
    Official Full Name
    chymotrypsin-like elastase family, member 2Aprovided by MGI
    Primary source
    MGI:MGI:95316
    See related
    Ensembl:ENSMUSG00000058579 AllianceGenome:MGI:95316
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ela2; Ela-2; Ela2a
    Summary
    This gene encodes a serine protease enzyme that hydrolyzes elastin. This gene is highly expressed in the pancreatic acinar cells where the encoded preproprotein undergoes processing including signal peptide cleavage to generate an inactive zymogen. The removal of N-terminal activation peptide from the zymogen by trypsin generates active elastase enzyme. This gene is also expressed in the mouse epidermis where it participates in pro-filaggrin processing. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in small intestine adult (RPKM 15206.1), spleen adult (RPKM 7098.1) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Cela2a in Genome Data Viewer
    Location:
    4 D3; 4 74.75 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141542265..141553316, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141814954..141826005, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene agmatinase Neighboring gene DnaJ heat shock protein family (Hsp40) member C16 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:141346676-141346859 Neighboring gene STARR-positive B cell enhancer ABC_E1042 Neighboring gene caspase 9 Neighboring gene chymotrypsin C Neighboring gene chymotrypsin C, opposite strand Neighboring gene predicted gene, 35034

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables serine hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in insulin catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of platelet aggregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to insulin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in keratohyalin granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    chymotrypsin-like elastase family member 2A
    Names
    elastase 2A
    NP_031945.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007919.3NP_031945.1  chymotrypsin-like elastase family member 2A preproprotein

      See identical proteins and their annotated locations for NP_031945.1

      Status: REVIEWED

      Source sequence(s)
      AL928577, CJ042539, CJ042553, CJ042571
      Consensus CDS
      CCDS18884.1
      UniProtKB/Swiss-Prot
      P05208
      Related
      ENSMUSP00000099539.4, ENSMUST00000102481.4
      Conserved Domains (2) summary
      smart00020
      Location:30264
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:31267
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      141542265..141553316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)