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    Kcnmb3 potassium large conductance calcium-activated channel, subfamily M, beta member 3 [ Mus musculus (house mouse) ]

    Gene ID: 100502876, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcnmb3provided by MGI
    Official Full Name
    potassium large conductance calcium-activated channel, subfamily M, beta member 3provided by MGI
    Primary source
    MGI:MGI:3612244
    See related
    Ensembl:ENSMUSG00000091091 AllianceGenome:MGI:3612244
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm5707; EG435726
    Summary
    Predicted to enable calcium-activated potassium channel activity and potassium channel regulator activity. Predicted to be involved in detection of calcium ion; neuronal action potential; and potassium ion transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human KCNMB3 (potassium calcium-activated channel subfamily M regulatory beta subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Kcnmb3 in Genome Data Viewer
    Location:
    3 A3; 3 15.73 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (32518995..32557045, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (32465146..32502896, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930429B21 gene Neighboring gene zinc finger matrin type 3 Neighboring gene STARR-seq mESC enhancer starr_07335 Neighboring gene STARR-seq mESC enhancer starr_07336 Neighboring gene STARR-positive B cell enhancer ABC_E7906 Neighboring gene predicted gene, 54172 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Neighboring gene STARR-positive B cell enhancer ABC_E6047 Neighboring gene STARR-seq mESC enhancer starr_07337 Neighboring gene STARR-positive B cell enhancer ABC_E6048 Neighboring gene STARR-seq mESC enhancer starr_07340 Neighboring gene STARR-positive B cell enhancer ABC_E2662 Neighboring gene zinc finger protein 639 Neighboring gene mitofusin 1 Neighboring gene STARR-seq mESC enhancer starr_07342 Neighboring gene guanine nucleotide binding protein (G protein), beta 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BK channels in microglia are required for morphine-induced hyperalgesia. Hayashi Y, et al. Nat Commun, 2016 May 31. PMID 27241733, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in detection of calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium-activated potassium channel subunit beta-3
    Names
    potassium large conductance calcium-activated channel, subfamily M, beta member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195074.1 → NP_001182003.1  calcium-activated potassium channel subunit beta-3

      Status: PROVISIONAL

      Source sequence(s)
      AC130281
      Consensus CDS
      CCDS57206.1
      UniProtKB/TrEMBL
      E9Q7U0
      Related
      ENSMUSP00000130177.2, ENSMUST00000164954.3
      Conserved Domains (1) summary
      pfam03185
      Location:41 → 232
      CaKB; Calcium-activated potassium channel, beta subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      32518995..32557045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319414.3 → XP_017174903.1  calcium-activated potassium channel subunit beta-3 isoform X1

      Conserved Domains (1) summary
      pfam03185
      Location:62 → 253
      CaKB; Calcium-activated potassium channel, beta subunit

    2. XM_011249654.4 → XP_011247956.1  calcium-activated potassium channel subunit beta-3 isoform X2

      Conserved Domains (1) summary
      pfam03185
      Location:20 → 211
      CaKB; Calcium-activated potassium channel, beta subunit
    Nucleotide Protein
    Heading Accession and Version

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