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    Gata5 GATA binding protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 14464, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gata5provided by MGI
    Official Full Name
    GATA binding protein 5provided by MGI
    Primary source
    MGI:MGI:109497
    See related
    Ensembl:ENSMUSG00000015627 AllianceGenome:MGI:109497
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including heart development; positive regulation of Notch signaling pathway; and regulation of gene expression. Acts upstream of or within cellular response to BMP stimulus and positive regulation of DNA-templated transcription. Located in chromatin. Is expressed in several structures, including branchial arch; genitourinary system; gut; heart; and respiratory system. Used to study essential hypertension. Human ortholog(s) of this gene implicated in artery disease (multiple); atrial fibrillation (multiple); congenital heart disease (multiple); and dilated cardiomyopathy. Orthologous to human GATA5 (GATA binding protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in small intestine adult (RPKM 33.7), duodenum adult (RPKM 29.2) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gata5 in Genome Data Viewer
    Location:
    2 H4; 2 102.85 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179966881..179977296, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180325088..180335503, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RBBP8 N-terminal like Neighboring gene predicted gene, 29943 Neighboring gene GATA binding protein 5, opposite strand Neighboring gene predicted gene, 52543 Neighboring gene RIKEN cDNA B230312C02 gene Neighboring gene Mir1a-1 and Mir133a-2 host gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (6)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in aortic valve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in aortic valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in cardiac jelly development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cellular response to BMP stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nitric oxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocardial cushion fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in heart induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intestinal epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of cardiac muscle hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic DNA fragmentation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic DNA fragmentation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac endothelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor GATA-5
    Names
    GATA-binding factor 5
    Transcription factor GATA-5 (GATA binding factor-5)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008093.2NP_032119.2  transcription factor GATA-5

      See identical proteins and their annotated locations for NP_032119.2

      Status: VALIDATED

      Source sequence(s)
      AK142213, AL663027
      Consensus CDS
      CCDS17175.1
      UniProtKB/Swiss-Prot
      P97489, Q3UQR0
      UniProtKB/TrEMBL
      Q0VGJ0
      Related
      ENSMUSP00000015771.3, ENSMUST00000015771.3
      Conserved Domains (2) summary
      cd00202
      Location:250300
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:1181
      GATA-N; GATA-type transcription activator, N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      179966881..179977296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500554.4XP_006500617.1  transcription factor GATA-5 isoform X1

      See identical proteins and their annotated locations for XP_006500617.1

      UniProtKB/Swiss-Prot
      P97489, Q3UQR0
      UniProtKB/TrEMBL
      Q0VGJ0
      Conserved Domains (2) summary
      cd00202
      Location:250300
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:1181
      GATA-N; GATA-type transcription activator, N-terminal