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    Hrh3 histamine receptor H3 [ Mus musculus (house mouse) ]

    Gene ID: 99296, updated on 3-Dec-2024

    Summary

    Official Symbol
    Hrh3provided by MGI
    Official Full Name
    histamine receptor H3provided by MGI
    Primary source
    MGI:MGI:2139279
    See related
    Ensembl:ENSMUSG00000039059 AllianceGenome:MGI:2139279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H3R; Eae8; HH3R
    Summary
    Predicted to enable several functions, including amine binding activity; histamine receptor activity; and neurotransmitter receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; learning or memory; and regulation of secretion. Predicted to be active in dendrite; plasma membrane; and synapse. Is expressed in brain. Orthologous to human HRH3 (histamine receptor H3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 17.2), cortex adult (RPKM 16.0) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hrh3 in Genome Data Viewer
    Location:
    2 H4; 2 102.62 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179741258..179746264, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180099465..180104484, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7897 Neighboring gene SS18, nBAF chromatin remodeling complex subunit like 1 Neighboring gene mitochondrial ribosome associated GTPase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:179830439-179830640 Neighboring gene predicted gene, 46782 Neighboring gene STARR-positive B cell enhancer ABC_E332 Neighboring gene oxysterol binding protein-like 2 Neighboring gene predicted gene, 29886

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    susceptibility to experimental allergic encephalomyelitis 8
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heterocyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histamine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histamine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables organic cyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cAMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in drinking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gamma-aminobutyric acid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of serotonin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of arachidonate secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of norepinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to forskolin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    histamine H3 receptor
    Names
    experimental allergic encephalomyelitis susceptibility 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409451.1NP_001396380.1  histamine H3 receptor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672130
      UniProtKB/TrEMBL
      Q3U1A2
    2. NM_001409452.1NP_001396381.1  histamine H3 receptor isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL672130
      UniProtKB/TrEMBL
      Q3USH0
    3. NM_001409453.1NP_001396382.1  histamine H3 receptor isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672130
      UniProtKB/TrEMBL
      B3Y5Z8
    4. NM_001409454.1NP_001396383.1  histamine H3 receptor isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL672130
      UniProtKB/TrEMBL
      Q3USH0
    5. NM_001409455.1NP_001396384.1  histamine H3 receptor isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL672130
      UniProtKB/TrEMBL
      Q3U1A2
    6. NM_001409456.1NP_001396385.1  histamine H3 receptor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672130
      UniProtKB/TrEMBL
      Q3U1A2
    7. NM_001409457.1NP_001396386.1  histamine H3 receptor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672130
      UniProtKB/TrEMBL
      Q3U1A2
    8. NM_001409458.1NP_001396387.1  histamine H3 receptor isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672130
      UniProtKB/TrEMBL
      Q3U1A2
    9. NM_133849.4NP_598610.1  histamine H3 receptor isoform 1

      See identical proteins and their annotated locations for NP_598610.1

      Status: VALIDATED

      Source sequence(s)
      AL672130
      Consensus CDS
      CCDS17169.1
      UniProtKB/Swiss-Prot
      P58406
      UniProtKB/TrEMBL
      B3Y5Z8, Q540P3
      Related
      ENSMUSP00000049963.4, ENSMUST00000056480.10
      Conserved Domains (1) summary
      pfam00001
      Location:51412
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      179741258..179746264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)