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    Csta3 cystatin A family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 408196, updated on 27-Nov-2024

    Summary

    Official Symbol
    Csta3provided by MGI
    Official Full Name
    cystatin A family member 3provided by MGI
    Primary source
    MGI:MGI:3644688
    See related
    Ensembl:ENSMUSG00000094733 AllianceGenome:MGI:3644688
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm5416; EG408196; Stfna1l1
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in several processes, including keratinocyte differentiation; negative regulation of peptidase activity; and peptide cross-linking. Predicted to be located in several cellular components, including cornified envelope; extracellular space; and nucleoplasm. Predicted to be part of peptidase inhibitor complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward liver E18 (RPKM 12.3) See more
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    Genomic context

    See Csta3 in Genome Data Viewer
    Location:
    16 B3; 16 25.43 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36030773..36038158)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36210403..36217788)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene zinc finger, BED domain containing 4 pseudogene Neighboring gene predicted pseudogene 10913 Neighboring gene STARR-seq mESC enhancer starr_40762 Neighboring gene cystatin A family member 2 Neighboring gene predicted gene, 24569

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide cross-linking ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of peptidase inhibitor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cystatin A family member 3
    Names
    stefin A1 like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082542.1NP_001076011.1  cystatin A family member 3 precursor

      See identical proteins and their annotated locations for NP_001076011.1

      Status: PROVISIONAL

      Source sequence(s)
      BN000365
      Consensus CDS
      CCDS37329.1
      UniProtKB/TrEMBL
      D3Z5J1, Q05B95, Q6IE28
      Related
      ENSMUSP00000087054.4, ENSMUST00000089628.4
      Conserved Domains (1) summary
      pfam00031
      Location:490
      Cystatin; Cystatin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      36030773..36038158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)