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    Cpb2 carboxypeptidase B2 [ Mus musculus (house mouse) ]

    Gene ID: 56373, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cpb2provided by MGI
    Official Full Name
    carboxypeptidase B2provided by MGI
    Primary source
    MGI:MGI:1891837
    See related
    Ensembl:ENSMUSG00000021999 AllianceGenome:MGI:1891837
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CPR; Cpu; TAFI; 1110032P04Rik; 4930405E17Rik
    Summary
    This gene encodes carboxypeptidase B, a zinc-dependent metalloprotease that cleaves peptide bonds at the C-terminus of protein substrates. The encoded preproprotein undergoes proteolytic activation to generate a mature, functional enzyme, and secreted into plasma. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in liver E18 (RPKM 213.1), liver adult (RPKM 49.9) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cpb2 in Genome Data Viewer
    Location:
    14 D3; 14 39.73 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (75479727..75520995)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (75242287..75283555)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 63 Neighboring gene predicted gene 15628 Neighboring gene STARR-positive B cell enhancer mm9_chr14:75576489-75576789 Neighboring gene STARR-seq mESC enhancer starr_37136 Neighboring gene STARR-positive B cell enhancer ABC_E4120 Neighboring gene lymphocyte cytosolic protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E8899 Neighboring gene STARR-positive B cell enhancer ABC_E7338 Neighboring gene STARR-positive B cell enhancer ABC_E7339 Neighboring gene predicted gene, 35679 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37139 Neighboring gene zinc finger CCCH type containing 13 Neighboring gene predicted gene, 46470 Neighboring gene STARR-seq mESC enhancer starr_37142 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:75845484-75845692 Neighboring gene predicted gene, 41212 Neighboring gene siah E3 ubiquitin protein ligase family member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC107573

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables carboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibrinolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in liver regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of fibrinolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hepatocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of hepatocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of plasminogen activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of plasminogen activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of extracellular matrix constituent secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of extracellular matrix constituent secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    carboxypeptidase B2
    Names
    carboxypeptidase B2 (plasma)
    carboxypeptidase R
    carboxypeptidase U
    thrombin-activable fibrinolysis inhibitor
    thrombin-activatable fibrinolysis inhibitor
    NP_062749.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019775.3NP_062749.2  carboxypeptidase B2 preproprotein

      See identical proteins and their annotated locations for NP_062749.2

      Status: REVIEWED

      Source sequence(s)
      AA048136, AK004045, CO807338
      Consensus CDS
      CCDS27277.1
      UniProtKB/Swiss-Prot
      Q5EBI3, Q9JHH6, Q9QZF0
      Related
      ENSMUSP00000022576.9, ENSMUST00000022576.10
      Conserved Domains (2) summary
      cd06246
      Location:118419
      M14_CPB2; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B2 subgroup
      pfam02244
      Location:32103
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      75479727..75520995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)