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    Wdr45b WD repeat domain 45B [ Mus musculus (house mouse) ]

    Gene ID: 66840, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wdr45bprovided by MGI
    Official Full Name
    WD repeat domain 45Bprovided by MGI
    Primary source
    MGI:MGI:1914090
    See related
    Ensembl:ENSMUSG00000025173 AllianceGenome:MGI:1914090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    WIPI-3; Wdr45l; D16Bwg0193e; 0610008N23Rik
    Summary
    Predicted to enable TSC1-TSC2 complex binding activity; phosphatidylinositol-3,5-bisphosphate binding activity; and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagy of mitochondrion; cellular response to starvation; and macroautophagy. Predicted to be located in lysosome and phagophore assembly site. Predicted to be active in cytosol and phagophore assembly site membrane. Orthologous to human WDR45B (WD repeat domain 45B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 23.7), ovary adult (RPKM 19.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Wdr45b in Genome Data Viewer
    Location:
    11 E2; 11 85.24 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (121218029..121246393, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121327203..121354447, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31378 Neighboring gene STARR-positive B cell enhancer ABC_E8883 Neighboring gene nuclear prelamin A recognition factor Neighboring gene forkhead box K2 Neighboring gene Rab40B, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_31380 Neighboring gene microRNA 7236 Neighboring gene STARR-positive B cell enhancer mm9_chr11:121282511-121282812 Neighboring gene fructosamine 3 kinase related protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables TSC1-TSC2 complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables TSC1-TSC2 complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagy of peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein lipidation involved in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in phagophore assembly site ISO
    Inferred from Sequence Orthology
    more info
     
    located_in phagophore assembly site ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    WD repeat domain phosphoinositide-interacting protein 3
    Names
    WD repeat-containing protein 45-like
    WD repeat-containing protein 45B
    WDR45-like protein
    Wdr45 like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025793.3NP_080069.2  WD repeat domain phosphoinositide-interacting protein 3

      See identical proteins and their annotated locations for NP_080069.2

      Status: VALIDATED

      Source sequence(s)
      AK146101, BY618193
      Consensus CDS
      CCDS25773.1
      UniProtKB/Swiss-Prot
      Q3U924, Q9CR39
      Related
      ENSMUSP00000026173.7, ENSMUST00000026173.13
      Conserved Domains (2) summary
      sd00039
      Location:145183
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:25258
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      121218029..121246393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001780040.2 RNA Sequence

    2. XR_004937006.1 RNA Sequence