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    Kat7 K(lysine) acetyltransferase 7 [ Mus musculus (house mouse) ]

    Gene ID: 217127, updated on 3-Dec-2024

    Summary

    Official Symbol
    Kat7provided by MGI
    Official Full Name
    K(lysine) acetyltransferase 7provided by MGI
    Primary source
    MGI:MGI:2182799
    See related
    Ensembl:ENSMUSG00000038909 AllianceGenome:MGI:2182799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hbo1; Hboa; Myst2
    Summary
    Enables histone H3K14 acetyltransferase activity. Involved in several processes, including lymphocyte differentiation; positive regulation of erythrocyte differentiation; and positive regulation of macromolecule biosynthetic process. Located in nucleus. Part of histone H3-K14 acetyltransferase complex. Is expressed in central nervous system; early conceptus; genitourinary system; and limb. Orthologous to human KAT7 (lysine acetyltransferase 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 20.1), placenta adult (RPKM 13.7) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kat7 in Genome Data Viewer
    Location:
    11 D; 11 59.01 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95162683..95201030, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95271853..95310246, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11515 Neighboring gene tachykinin 4 Neighboring gene STARR-positive B cell enhancer ABC_E9370 Neighboring gene STARR-positive B cell enhancer ABC_E9840 Neighboring gene STARR-positive B cell enhancer ABC_E376 Neighboring gene STARR-positive B cell enhancer ABC_E1841 Neighboring gene predicted gene 11520 Neighboring gene STARR-seq mESC enhancer starr_30502 Neighboring gene STARR-positive B cell enhancer ABC_E594 Neighboring gene family with sequence similarity 117, member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC56758

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA replication origin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H2AK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AK9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BK12 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BK5 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K122 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K14 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K14 acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3K14 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K14 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H3K18 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K23 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K23 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K27 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K36 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K4 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K56 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K9 acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H4 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H4K12 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H4K12 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT enables histone H4K16 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H4K5 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H4K5 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H4K8 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H4K8 acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication-dependent chromatin disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA replication-dependent chromatin disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in internal peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in internal peptidyl-lysine acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription, elongation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of hematopoietic stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of hematopoietic stem cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated DNA replication initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of nucleotide-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to actinomycin D ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to anisomycin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to dithiothreitol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hydroxyurea ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to sorbitol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress-activated protein kinase signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription initiation-coupled chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone H3-K14 acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of histone H3-K14 acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of histone H3-K14 acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of DNA damage ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    histone acetyltransferase KAT7
    Names
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
    MYST histone acetyltransferase 2
    histone acetyltransferase MYST2
    histone acetyltransferase binding to ORC1
    lysine acetyltransferase 7
    NP_001181932.1
    NP_001181933.1
    NP_001392123.1
    NP_001392124.1
    NP_001392125.1
    NP_001392126.1
    NP_001392127.1
    NP_001392128.1
    NP_001392129.1
    NP_001392130.1
    NP_001392131.1
    NP_001392132.1
    NP_001392133.1
    NP_001392134.1
    NP_001392135.1
    NP_001392136.1
    NP_001392137.1
    NP_001392138.1
    NP_001392139.1
    NP_001392140.1
    NP_001392141.1
    NP_001392142.1
    NP_001392143.1
    NP_001392144.1
    NP_001392145.1
    NP_001392146.1
    NP_001392147.1
    NP_001392148.1
    NP_001392149.1
    NP_001392150.1
    NP_001392151.1
    NP_001392152.1
    NP_001392153.1
    NP_001392154.1
    NP_001392155.1
    NP_001392156.1
    NP_808287.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195003.2NP_001181932.1  histone acetyltransferase KAT7 isoform 1

      See identical proteins and their annotated locations for NP_001181932.1

      Status: VALIDATED

      Source sequence(s)
      AL627222
      Consensus CDS
      CCDS56799.1
      UniProtKB/TrEMBL
      A0AA74KSS6, Q1AJD0
      Related
      ENSMUSP00000103362.4, ENSMUST00000107734.10
      Conserved Domains (3) summary
      PLN00104
      Location:324609
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam05109
      Location:27197
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01530
      Location:184212
      zf-C2HC; Zinc finger, C2HC type
    2. NM_001195004.2NP_001181933.1  histone acetyltransferase KAT7 isoform 2

      See identical proteins and their annotated locations for NP_001181933.1

      Status: VALIDATED

      Source sequence(s)
      AL627222
      Consensus CDS
      CCDS56798.1
      UniProtKB/TrEMBL
      A0AA74KSS6, Q3TD41
      Related
      ENSMUSP00000103361.4, ENSMUST00000107733.10
      Conserved Domains (4) summary
      PLN00104
      Location:294579
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam05109
      Location:27197
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd16378
      Location:209262
      CcmH_N; N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins
      pfam01530
      Location:184212
      zf-C2HC; Zinc finger, C2HC type
    3. NM_001405194.1NP_001392123.1  histone acetyltransferase KAT7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/Swiss-Prot
      Q5SVQ0, Q5SVQ1, Q5SVQ2, Q5SVQ3, Q5SVQ7, Q6PGC6, Q80Y65
      UniProtKB/TrEMBL
      Q3UGF2
      Related
      ENSMUSP00000090441.6, ENSMUST00000092766.12
    4. NM_001405195.1NP_001392124.1  histone acetyltransferase KAT7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      A0AA74KSS6
    5. NM_001405196.1NP_001392125.1  histone acetyltransferase KAT7 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      A0AA74KSS6
    6. NM_001405197.1NP_001392126.1  histone acetyltransferase KAT7 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      Q3UGF2
      Related
      ENSMUSP00000072416.6, ENSMUST00000072621.12
    7. NM_001405198.1NP_001392127.1  histone acetyltransferase KAT7 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      A0AA74KSS6
    8. NM_001405199.1NP_001392128.1  histone acetyltransferase KAT7 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      A0AA74KSS6
    9. NM_001405200.1NP_001392129.1  histone acetyltransferase KAT7 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      A0AA74KSS6
    10. NM_001405201.1NP_001392130.1  histone acetyltransferase KAT7 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      Q3UGF2
    11. NM_001405202.1NP_001392131.1  histone acetyltransferase KAT7 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      Q3UGF2
    12. NM_001405203.1NP_001392132.1  histone acetyltransferase KAT7 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      A0AA74KSS6
    13. NM_001405204.1NP_001392133.1  histone acetyltransferase KAT7 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      Q3UGF2
    14. NM_001405205.1NP_001392134.1  histone acetyltransferase KAT7 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      A0AA74KSS6
    15. NM_001405206.1NP_001392135.1  histone acetyltransferase KAT7 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      A0AA74KSS6
    16. NM_001405207.1NP_001392136.1  histone acetyltransferase KAT7 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      A0AA74KSS6
    17. NM_001405208.1NP_001392137.1  histone acetyltransferase KAT7 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      Q3UGF2
    18. NM_001405209.1NP_001392138.1  histone acetyltransferase KAT7 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AL627222
    19. NM_001405210.1NP_001392139.1  histone acetyltransferase KAT7 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AL627222
    20. NM_001405211.1NP_001392140.1  histone acetyltransferase KAT7 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      Q3UGU8
    21. NM_001405212.1NP_001392141.1  histone acetyltransferase KAT7 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AL627222
    22. NM_001405213.1NP_001392142.1  histone acetyltransferase KAT7 isoform 23

      Status: VALIDATED

      Source sequence(s)
      AL627222
    23. NM_001405214.1NP_001392143.1  histone acetyltransferase KAT7 isoform 24

      Status: VALIDATED

      Source sequence(s)
      AL627222
    24. NM_001405215.1NP_001392144.1  histone acetyltransferase KAT7 isoform 25

      Status: VALIDATED

      Source sequence(s)
      AL627222
    25. NM_001405216.1NP_001392145.1  histone acetyltransferase KAT7 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      Q3UGU8
    26. NM_001405217.1NP_001392146.1  histone acetyltransferase KAT7 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      Q3UGU8
    27. NM_001405218.1NP_001392147.1  histone acetyltransferase KAT7 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      Q3UGU8
    28. NM_001405219.1NP_001392148.1  histone acetyltransferase KAT7 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AL627222
      UniProtKB/TrEMBL
      Q3UGU8
    29. NM_001405220.1NP_001392149.1  histone acetyltransferase KAT7 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AL627222
    30. NM_001405221.1NP_001392150.1  histone acetyltransferase KAT7 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AL627222
    31. NM_001405222.1NP_001392151.1  histone acetyltransferase KAT7 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AL627222
    32. NM_001405223.1NP_001392152.1  histone acetyltransferase KAT7 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AL627222
    33. NM_001405224.1NP_001392153.1  histone acetyltransferase KAT7 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AL627222
    34. NM_001405225.1NP_001392154.1  histone acetyltransferase KAT7 isoform 23

      Status: VALIDATED

      Source sequence(s)
      AL627222
    35. NM_001405226.1NP_001392155.1  histone acetyltransferase KAT7 isoform 25

      Status: VALIDATED

      Source sequence(s)
      AL627222
    36. NM_001405227.1NP_001392156.1  histone acetyltransferase KAT7 isoform 26

      Status: VALIDATED

      Source sequence(s)
      AL627222
    37. NM_177619.4NP_808287.1  histone acetyltransferase KAT7 isoform 3

      See identical proteins and their annotated locations for NP_808287.1

      Status: VALIDATED

      Source sequence(s)
      AL627222
      Consensus CDS
      CCDS25275.1
      UniProtKB/TrEMBL
      A0AA74KSS6
      Related
      ENSMUSP00000099448.4, ENSMUST00000103159.10
      Conserved Domains (2) summary
      pfam01530
      Location:125153
      zf-C2HC; Zinc finger, C2HC type
      cl27485
      Location:235520
      MOZ_SAS; MOZ/SAS family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      95162683..95201030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)