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    Dlx4 distal-less homeobox 4 [ Mus musculus (house mouse) ]

    Gene ID: 13394, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dlx4provided by MGI
    Official Full Name
    distal-less homeobox 4provided by MGI
    Primary source
    MGI:MGI:94904
    See related
    Ensembl:ENSMUSG00000020871 AllianceGenome:MGI:94904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dlx7; Dlx-4
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; embryonic skeletal system development; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Is expressed in several structures, including branchial arch; central nervous system; jaw; limb ectoderm; and urinary system. Human ortholog(s) of this gene implicated in orofacial cleft 15. Orthologous to human DLX4 (distal-less homeobox 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Dlx4 in Genome Data Viewer
    Location:
    11 D; 11 59.01 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (95031273..95037116, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (95140447..95146294, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene distal-less homeobox 3 Neighboring gene DNA damage-induced stem cell specific noncoding RNA Neighboring gene distal-less homeobox 4, opposite strand Neighboring gene predicted gene 11514 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:95045922-95046123 Neighboring gene predicted gene, 53255

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC129167

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in embryonic skeletal system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    homeobox protein DLX-4
    Names
    DII D
    distal-less homeo box 7
    homeobox protein DLX-7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007867.4NP_031893.3  homeobox protein DLX-4

      Status: VALIDATED

      Source sequence(s)
      AL645850
      Consensus CDS
      CCDS25273.1
      UniProtKB/Swiss-Prot
      P70436, Q3UM51, Q8R4I3
      Related
      ENSMUSP00000021241.7, ENSMUST00000021241.8
      Conserved Domains (1) summary
      pfam00046
      Location:119172
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      95031273..95037116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245519.2XP_030101379.1  homeobox protein DLX-4 isoform X1