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    Uts2r urotensin 2 receptor [ Mus musculus (house mouse) ]

    Gene ID: 217369, updated on 9-Dec-2024

    Summary

    Official Symbol
    Uts2rprovided by MGI
    Official Full Name
    urotensin 2 receptorprovided by MGI
    Primary source
    MGI:MGI:2183450
    See related
    Ensembl:ENSMUSG00000039321 AllianceGenome:MGI:2183450
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UTR; UTR2; Gpr14; UR-2-R
    Summary
    Predicted to enable urotensin II receptor activity. Predicted to be involved in several processes, including neuropeptide signaling pathway; regulation of blood pressure; and regulation of circadian sleep/wake cycle. Predicted to be located in early endosome and recycling endosome. Predicted to be active in plasma membrane. Orthologous to human UTS2R (urotensin 2 receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Uts2r in Genome Data Viewer
    Location:
    11 E2; 11 85.02 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (121051097..121052799)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121160271..121161973)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene testis expressed gene 19.2 Neighboring gene STARR-seq mESC enhancer starr_31377 Neighboring gene testis expressed gene 19.1 Neighboring gene bromodomain containing 4 pseudogene Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E7117 Neighboring gene hexosaminidase D

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables urotensin II receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables urotensin II receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables urotensin II receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood vessel diameter maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glomerular filtration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of urine volume ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of circadian sleep/wake cycle, REM sleep ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of circadian sleep/wake cycle, wakefulness ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    urotensin-2 receptor
    Names
    G protein-coupled receptor 14
    UR-II-R
    urotensin II receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145440.1NP_663415.1  urotensin-2 receptor

      See identical proteins and their annotated locations for NP_663415.1

      Status: PROVISIONAL

      Source sequence(s)
      AF441863
      Consensus CDS
      CCDS25769.1
      UniProtKB/Swiss-Prot
      Q8VIH9
      UniProtKB/TrEMBL
      Q05AD1
      Related
      ENSMUSP00000046920.2, ENSMUST00000039044.2
      Conserved Domains (1) summary
      pfam00001
      Location:72316
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      121051097..121052799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)