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    Map3k3 mitogen-activated protein kinase kinase kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 26406, updated on 9-Dec-2024

    Summary

    Official Symbol
    Map3k3provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase 3provided by MGI
    Primary source
    MGI:MGI:1346874
    See related
    Ensembl:ENSMUSG00000020700 AllianceGenome:MGI:1346874
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mekk3; MAPKKK3; mKIAA4031
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within blood vessel development and positive regulation of p38MAPK cascade. Predicted to be active in cytoplasm. Is expressed in several structures, including early conceptus; heart; and metanephros. Orthologous to human MAP3K3 (mitogen-activated protein kinase kinase kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 22.2), subcutaneous fat pad adult (RPKM 19.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Map3k3 in Genome Data Viewer
    Location:
    11 E1; 11 68.89 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105975358..106047482)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106084587..106156656)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:105927234-105927440 Neighboring gene STARR-seq mESC enhancer starr_30915 Neighboring gene STARR-positive B cell enhancer ABC_E2372 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I Neighboring gene STARR-positive B cell enhancer ABC_E258 Neighboring gene STARR-seq mESC enhancer starr_30916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106020710-106020950 Neighboring gene predicted gene 10840 Neighboring gene LIM domain containing 2 Neighboring gene STE20-related kinase adaptor alpha Neighboring gene STARR-positive B cell enhancer ABC_E7078 Neighboring gene STARR-positive B cell enhancer ABC_E739

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA4031

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables JUN kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 3
    Names
    MAPK/ERK kinase kinase 3
    MEK kinase 3
    MEKK 3
    NP_036077.1
    XP_011247339.1
    XP_036012603.1
    XP_036012604.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011947.4NP_036077.1  mitogen-activated protein kinase kinase kinase 3

      See identical proteins and their annotated locations for NP_036077.1

      Status: VALIDATED

      Source sequence(s)
      AL596331
      Consensus CDS
      CCDS25548.1
      UniProtKB/Swiss-Prot
      Q61084
      UniProtKB/TrEMBL
      Q3UVM5
      Related
      ENSMUSP00000002044.10, ENSMUST00000002044.10
      Conserved Domains (3) summary
      cd06405
      Location:45123
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      smart00220
      Location:362621
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06625
      Location:361621
      STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      105975358..106047482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156711.1XP_036012604.1  mitogen-activated protein kinase kinase kinase 3 isoform X2

      UniProtKB/TrEMBL
      Q3UVM5
      Conserved Domains (2) summary
      cd06405
      Location:45123
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cl21453
      Location:361577
      PKc_like; Protein Kinases, catalytic domain
    2. XM_011249037.4XP_011247339.1  mitogen-activated protein kinase kinase kinase 3 isoform X1

      UniProtKB/TrEMBL
      Q3UVM5
      Conserved Domains (2) summary
      cd06405
      Location:35113
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06625
      Location:351611
      STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases
    3. XM_036156710.1XP_036012603.1  mitogen-activated protein kinase kinase kinase 3 isoform X1

      UniProtKB/TrEMBL
      Q3UVM5
      Conserved Domains (2) summary
      cd06405
      Location:35113
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06625
      Location:351611
      STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases

    RNA

    1. XR_004936967.1 RNA Sequence