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    Itgb3 integrin beta 3 [ Mus musculus (house mouse) ]

    Gene ID: 16416, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itgb3provided by MGI
    Official Full Name
    integrin beta 3provided by MGI
    Primary source
    MGI:MGI:96612
    See related
    Ensembl:ENSMUSG00000020689 AllianceGenome:MGI:96612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD61; GP3A; INGRB3
    Summary
    Enables integrin binding activity and protein kinase C binding activity. Involved in several processes, including positive regulation of T cell migration; positive regulation of osteoblast proliferation; and regulation of serotonin uptake. Acts upstream of or within several processes, including blood coagulation; positive regulation of cell-substrate adhesion; and regulation of cell migration. Located in several cellular components, including apical plasma membrane; external side of plasma membrane; and focal adhesion. Part of alpha9-beta1 integrin-ADAM8 complex and alphav-beta3 integrin-PKCalpha complex. Is active in glutamatergic synapse and synaptic membrane. Is expressed in several structures, including brain; dorsal aorta; gut; liver; and urinary system. Used to study Glanzmann's thrombasthenia and platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (integrin subunit beta 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 21.3), ovary adult (RPKM 17.5) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Itgb3 in Genome Data Viewer
    Location:
    11 E1; 11 67.84 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (104498826..104561302)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (104608000..104670476)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5284 Neighboring gene STARR-positive B cell enhancer ABC_E7075 Neighboring gene STARR-seq mESC enhancer starr_30892 Neighboring gene myosin, light polypeptide 4 Neighboring gene lin-52 DREAM MuvB core complex component, pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr11:104469193-104469494 Neighboring gene non-histone chromosomal protein HMG-14 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr11:104483926-104484227 Neighboring gene STARR-positive B cell enhancer ABC_E1434 Neighboring gene ribosomal protein L3 pseudogene Neighboring gene EF-hand calcium binding domain 3 Neighboring gene STARR-seq mESC enhancer starr_30895 Neighboring gene STARR-seq mESC enhancer starr_30896 Neighboring gene STARR-seq mESC enhancer starr_30897 Neighboring gene high mobility group box 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC159221, MGC159223

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to C-X3-C chemokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to C-X3-C chemokine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables extracellular matrix binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables extracellular matrix binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to fibrinogen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fibrinogen binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to fibrinogen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fibroblast growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fibronectin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fibronectin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin-like growth factor I binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to insulin-like growth factor I binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to neuregulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to neuregulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein disulfide isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables vascular endothelial growth factor receptor 2 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables vascular endothelial growth factor receptor 2 binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apolipoprotein A-I-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apolipoprotein A-I-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic cell clearance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in apoptotic cell clearance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blood coagulation, fibrin clot formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion mediated by integrin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell projection morphogenesis IC
    Inferred by Curator
    more info
    PubMed 
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell-matrix adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-matrix adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell-substrate junction assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to insulin-like growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to platelet-derived growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryo implantation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in integrin-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in maintenance of postsynaptic specialization structure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of postsynaptic specialization structure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mesodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid storage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of lipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipoprotein metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of lipoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of low-density lipoprotein receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of macrophage derived foam cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet aggregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of bone resorption IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of glomerular mesangial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of glomerular mesangial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of osteoclast differentiation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of serotonin uptake IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of trophoblast cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in symbiont entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of alpha9-beta1 integrin-ADAM8 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of alphav-beta3 integrin-HMGB1 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of alphav-beta3 integrin-HMGB1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of alphav-beta3 integrin-IGF-1-IGF1R complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of alphav-beta3 integrin-IGF-1-IGF1R complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of alphav-beta3 integrin-PKCalpha complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of alphav-beta3 integrin-PKCalpha complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in filopodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glycinergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glycinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alpha9-beta1 complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of integrin alphaIIb-beta3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin alphav-beta3 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of integrin alphav-beta3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of integrin complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in melanosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic membrane IEP
    Inferred from Expression Pattern
    more info
    PubMed 

    General protein information

    Preferred Names
    integrin beta-3
    Names
    GPIIIa
    platelet glycoprotein IIIa (GP3A)
    platelet gpIIIa
    platelet membrane glycoprotein IIIa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016780.2NP_058060.2  integrin beta-3 precursor

      See identical proteins and their annotated locations for NP_058060.2

      Status: VALIDATED

      Source sequence(s)
      BC125520, BQ033439, BX000996
      Consensus CDS
      CCDS25536.1
      UniProtKB/Swiss-Prot
      O54890, Q3TZC6
      Related
      ENSMUSP00000021028.5, ENSMUST00000021028.5
      Conserved Domains (3) summary
      pfam00362
      Location:37460
      Integrin_beta; Integrin, beta chain
      pfam07965
      Location:633716
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:743785
      Integrin_b_cyt; Integrin beta cytoplasmic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      104498826..104561302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532312.4XP_006532375.1  integrin beta-3 isoform X1

      Conserved Domains (4) summary
      smart00187
      Location:18441
      INB; Integrin beta subunits (N-terminal portion of extracellular region)
      pfam07965
      Location:614697
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:724766
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      pfam18372
      Location:443472
      I-EGF_1; Integrin beta epidermal growth factor like domain 1