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    Gnaz guanine nucleotide binding protein, alpha z subunit [ Mus musculus (house mouse) ]

    Gene ID: 14687, updated on 3-Dec-2024

    Summary

    Official Symbol
    Gnazprovided by MGI
    Official Full Name
    guanine nucleotide binding protein, alpha z subunitprovided by MGI
    Primary source
    MGI:MGI:95780
    See related
    Ensembl:ENSMUSG00000040009 AllianceGenome:MGI:95780
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gz
    Summary
    Enables adenylate cyclase inhibitor activity. Involved in negative regulation of insulin secretion. Acts upstream of or within G protein-coupled serotonin receptor signaling pathway. Located in cell body and dendrite. Is active in plasma membrane and synapse. Is expressed in early conceptus; early tubule; gonad; and nervous system. Orthologous to human GNAZ (G protein subunit alpha z). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 15.8), cortex adult (RPKM 13.8) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gnaz in Genome Data Viewer
    Location:
    10 B5.3; 10 38.48 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (74803009..74852739)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (74967177..75016907)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 1-like pseudogene Neighboring gene predicted gene 6419 Neighboring gene STARR-seq mESC enhancer starr_27145 Neighboring gene radial spoke head homolog 14 (Chlamydomonas) Neighboring gene predicted gene, 40692 Neighboring gene RAB36, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled serotonin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled serotonin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-protein beta/gamma-subunit complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables adenylate cyclase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterotrimeric G-protein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(z) subunit alpha
    Names
    g(x) alpha chain
    gz-alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358848.2NP_001345777.1  guanine nucleotide-binding protein G(z) subunit alpha

      Status: VALIDATED

      Source sequence(s)
      AC142500
      Consensus CDS
      CCDS23922.1
      UniProtKB/Swiss-Prot
      O70442, O70443, Q61637, Q91WM4
      UniProtKB/TrEMBL
      Q3UYF9, Q542R8
      Related
      ENSMUSP00000124639.2, ENSMUST00000159991.2
      Conserved Domains (1) summary
      cd00066
      Location:34349
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    2. NM_001428502.1NP_001415431.1  guanine nucleotide-binding protein G(z) subunit alpha

      Status: VALIDATED

      Source sequence(s)
      AC142500
      UniProtKB/Swiss-Prot
      O70442, O70443, Q61637, Q91WM4
      UniProtKB/TrEMBL
      Q3UYF9, Q542R8
    3. NM_010311.5NP_034441.1  guanine nucleotide-binding protein G(z) subunit alpha

      See identical proteins and their annotated locations for NP_034441.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AC142500
      Consensus CDS
      CCDS23922.1
      UniProtKB/Swiss-Prot
      O70442, O70443, Q61637, Q91WM4
      UniProtKB/TrEMBL
      Q3UYF9, Q542R8
      Related
      ENSMUSP00000036087.5, ENSMUST00000037813.5
      Conserved Domains (1) summary
      cd00066
      Location:34349
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      74803009..74852739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513235.5XP_006513298.1  guanine nucleotide-binding protein G(z) subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_006513298.1

      UniProtKB/Swiss-Prot
      O70442, O70443, Q61637, Q91WM4
      UniProtKB/TrEMBL
      Q3UYF9, Q542R8
      Conserved Domains (1) summary
      cd00066
      Location:34349
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    2. XM_006513236.2XP_006513299.1  guanine nucleotide-binding protein G(z) subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_006513299.1

      UniProtKB/Swiss-Prot
      O70442, O70443, Q61637, Q91WM4
      UniProtKB/TrEMBL
      Q3UYF9, Q542R8
      Conserved Domains (1) summary
      cd00066
      Location:34349
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)