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    RAB9A RAB9A, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 9367, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RAB9Aprovided by HGNC
    Official Full Name
    RAB9A, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9792
    See related
    Ensembl:ENSG00000123595 MIM:300284; AllianceGenome:HGNC:9792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAB9
    Summary
    Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in negative regulation by host of symbiont catalytic activity; positive regulation of exocytosis; and regulation of protein localization. Located in late endosome; lysosome; and phagocytic vesicle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal (RPKM 21.5), bone marrow (RPKM 11.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RAB9A in Genome Data Viewer
    Location:
    Xp22.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (13689128..13710504)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (13270511..13291900)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (13707247..13728623)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chrX:13671061-13671372 Neighboring gene uncharacterized LOC107985657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29442 Neighboring gene uncharacterized LOC107985656 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:13687079-13688278 Neighboring gene transcription elongation factor A N-terminal and central domain containing Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20668 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:13710181-13710377 Neighboring gene trafficking protein particle complex subunit 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:13752241-13753440 Neighboring gene OFD1 centriole and centriolar satellite protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:13778869-13779368 Neighboring gene glycoprotein M6B Neighboring gene NANOG hESC enhancer GRCh37_chrX:13820205-13820738 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:13845691-13846890

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rab GDI: a solubilizing and recycling factor for rab9 protein. Soldati T, et al. Mol Biol Cell, 1993 Apr. PMID 8389620, Free PMC Article
    2. RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells. Sun P, et al. Biomed Res Int, 2020. PMID 32420351, Free PMC Article
    3. Noncanonical Rab9a action supports retromer-mediated endosomal exit of human papillomavirus during virus entry. Choi J, et al. PLoS Pathog, 2023 Sep. PMID 37703297, Free PMC Article
    4. Rab9A is required for delivery of cargo from recycling endosomes to melanosomes. Mahanty S, et al. Pigment Cell Melanoma Res, 2016 Jan. PMID 26527546, Free PMC Article
    5. Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway. Zhu Y, et al. Technol Cancer Res Treat, 2020 Jan-Dec. PMID 32301398, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CALCOCO2/NDP52 associates with RAB9 to initiate an antiviral response to hepatitis B virus infection through a lysosomal degradation pathway.
      Title: CALCOCO2/NDP52 associates with RAB9 to initiate an antiviral response to hepatitis B virus infection through a lysosomal degradation pathway.
    2. Noncanonical Rab9a action supports retromer-mediated endosomal exit of human papillomavirus during virus entry.
      Title: Noncanonical Rab9a action supports retromer-mediated endosomal exit of human papillomavirus during virus entry.
    3. Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.
      Title: Rab9 Mediates Pancreatic Autophagy Switch From Canonical to Noncanonical, Aggravating Experimental Pancreatitis.
    4. Loss of androgen receptor promotes HCC invasion and metastasis via activating circ-LNPEP/miR-532-3p/RAB9A signal under hypoxia.
      Title: Loss of androgen receptor promotes HCC invasion and metastasis via activating circ-LNPEP/miR-532-3p/RAB9A signal under hypoxia.
    5. RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells.
      Title: RAB9A Plays an Oncogenic Role in Human Liver Cancer Cells.
    6. Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway.
      Title: Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway.
    7. Authors predicted the binding between RAB9A and miR-150-5p, and the direct interaction between RAB9A and miR-150-5p was confirmed by luciferase reporter and RNA immunoprecipitation assays. We also showed that RAB9A expression was regulated negatively by miR-150-5p, but was regulated positively by ZFAS1.
      Title: Long noncoding RNA ZFAS1 promotes tumorigenesis through regulation of miR-150-5p/RAB9A in melanoma.
    8. RAB9 competes with the catalytic subunit PPP2CA in binding to PPP2R1A. This competitive association has an important role in controlling the PP2A catalytic activity.
      Title: A subset of RAB proteins modulates PP2A phosphatase activity.
    9. protein kinase C modulates alpha1B-adrenergic receptor transfer to late endosomes and that Rab9 regulates this process and participates in G protein-mediated signaling turn-off.
      Title: Protein Kinase C Activation Promotes α(1B)-Adrenoceptor Internalization and Late Endosome Trafficking through Rab9 Interaction. Role in Heterologous Desensitization.
    10. Rab9A and its co-regulatory GTPases control STX13-mediated cargo delivery to maturing melanosomes.
      Title: Rab9A is required for delivery of cargo from recycling endosomes to melanosomes.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of RAB9A, member RAS oncogene family (RAB9A) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef disrupts Rab9-GCC2 interaction (in HEK-293 cells) resulting in delocalization of CI-MPR resulting in elevated secretion of hexosaminidase in HEK-293 cells PubMed
    Pr55(Gag) gag HIV-1 Gag co-localizes with Rab9 and TGN38 in endosomes and trans-Golgi compartments PubMed
    gag HIV-1 Gag co-localizes with Rab7-, Rab9-, and LAMP1-containing membranes at cytoplasmic and juxtanuclear sites in Staufen1-depleted cells PubMed
    gag Depletion of Rab9 by siRNA sequesters HIV-1 Gag within cells and causes a reduction in particle release PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation by host of symbiont catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in melanosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in phagocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in transport vesicle TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-9A
    Names
    RAB9, member RAS oncogene family

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195328.2 → NP_001182257.1  ras-related protein Rab-9A

      See identical proteins and their annotated locations for NP_001182257.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC003037, AK290505, BC017265, CF528703, DA141710
      Consensus CDS
      CCDS14156.1
      UniProtKB/Swiss-Prot
      A8K390, P51151, Q6ICN1
      Related
      ENSP00000480777.1, ENST00000618931.2
      Conserved Domains (1) summary
      cd04116
      Location:3 → 172
      Rab9; Rab GTPase family 9 (Rab9)

    2. NM_004251.5 → NP_004242.1  ras-related protein Rab-9A

      See identical proteins and their annotated locations for NP_004242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC003037, BC017265, CF528703, DA141710
      Consensus CDS
      CCDS14156.1
      UniProtKB/Swiss-Prot
      A8K390, P51151, Q6ICN1
      Related
      ENSP00000420127.1, ENST00000464506.2
      Conserved Domains (1) summary
      cd04116
      Location:3 → 172
      Rab9; Rab GTPase family 9 (Rab9)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      13689128..13710504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442645.1 → XP_047298601.1  ras-related protein Rab-9A isoform X1

      UniProtKB/Swiss-Prot
      A8K390, P51151, Q6ICN1

    2. XM_047442644.1 → XP_047298600.1  ras-related protein Rab-9A isoform X1

      UniProtKB/Swiss-Prot
      A8K390, P51151, Q6ICN1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      13270511..13291900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328136.1 → XP_054184111.1  ras-related protein Rab-9A isoform X1

      UniProtKB/Swiss-Prot
      A8K390, P51151, Q6ICN1

    2. XM_054328135.1 → XP_054184110.1  ras-related protein Rab-9A isoform X1

      UniProtKB/Swiss-Prot
      A8K390, P51151, Q6ICN1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51151.1 GenPept UniProtKB/Swiss-Prot:P51151

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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