GACAT3 gastric cancer associated transcript 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GACAT3provided by HGNC
Official Full Name: gastric cancer associated transcript 3provided by HGNC
Primary source: HGNC:HGNC:50847
See related: Ensembl:ENSG00000236289 MIM:616132; AllianceGenome:HGNC:50847
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LINC01458; lncRNA-AC130710
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 2p24.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (16050427..16085689)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (16082001..16117298)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (16190549..16225811)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNAs GACAT3 and LINC00152 regulate each other through miR-103 and are associated with clinicopathological characteristics in colorectal cancer.
Title: LncRNAs GACAT3 and LINC00152 regulate each other through miR-103 and are associated with clinicopathological characteristics in colorectal cancer.
High LncRNA-GACAT3 expression is associated with breast cancer.
Title: Association of LncRNA-GACAT3 with MRI features of breast cancer and its molecular mechanism.
Long noncoding RNA GACAT3 regulates the expression of NAMPT to promote glioma progression by sponging miR-135a.
Title: Long noncoding RNA GACAT3 promotes glioma progression by sponging miR-135a.
This study elucidated that GACAT3/miR-3127-5p/ELAVL1 signaling regulates glioma development and might be a promising therapeutic target.
Title: Long noncoding RNA gastric cancer-associated transcript 3 plays oncogenic roles in glioma through sponging miR-3127-5p.
GACAT3 promotes breast cancer malignancy by sponging miR-497, leading to the enhancement of its endogenous target CCND2. These results suggest that GACAT3/miR-497/CCND2 is a potential therapeutic target and biomarker for breast cancer
Title: LncRNA GACAT3 predicts poor prognosis and promotes cell proliferation in breast cancer through regulation of miR-497/CCND2.
Study demonstrate that GACAT3 acts as a competing endogenous RNA of HMGA1. Its knockdown resulted in significantly decreased cell proliferation of gastric cancer cells, similar to the effect of an HMGA1 knockdown.
Title: LncRNA GACAT3 acts as a competing endogenous RNA of HMGA1 and alleviates cucurbitacin B-induced apoptosis of gastric cancer cells.
GACAT3 directly binds to microRNA-497 and promotes gastric cancer progression.
Title: LncRNA GACAT3 promotes gastric cancer progression by negatively regulating miR-497 expression.
as a downstream target of the IL6/STAT3 signaling, Long non-coding RNA GACAT3 promotes gastric cancer cell growth suggesting that GACAT3 is an inflammatory response gene and may be served as a valuable potential target for the treatment of gastric cancer.
Title: Novel long non-coding RNA GACAT3 promotes gastric cancer cell proliferation through the IL-6/STAT3 signaling pathway.
lncRNA-AC130710 may be a potential tumor marker for gastric cancer prognosis
Title: lncRNA-AC130710 targeting by miR-129-5p is upregulated in gastric cancer and associates with poor prognosis.
Studies suggest that GACAT2 (long noncoding RNA HMlincRNA717) and GACAT3 (long noncoding RNA AC130710) may play crucial roles in the occurrence, development and diagnosis of gastric carcinoma.
Title: Long noncoding RNA HMlincRNA717 and AC130710 have been officially named as gastric cancer associated transcript 2 (GACAT2) and GACAT3, respectively.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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General gene information

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Other Names

gastric cancer associated transcript 3 (non-protein coding)
long intergenic non-protein coding RNA 1458

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.