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    AJUBA ajuba LIM protein [ Homo sapiens (human) ]

    Gene ID: 84962, updated on 4-Jan-2025

    Summary

    Official Symbol
    AJUBAprovided by HGNC
    Official Full Name
    ajuba LIM proteinprovided by HGNC
    Primary source
    HGNC:HGNC:20250
    See related
    Ensembl:ENSG00000129474 MIM:609066; AllianceGenome:HGNC:20250
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JUB
    Summary
    Enables alpha-catenin binding activity and transcription corepressor activity. Involved in several processes, including miRNA-mediated gene silencing by inhibition of translation; negative regulation of hippo signaling; and regulation of cellular response to hypoxia. Acts upstream of or within miRNA-mediated post-transcriptional gene silencing and positive regulation of protein-containing complex assembly. Located in several cellular components, including Golgi apparatus; P-body; and nucleoplasm. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in skin (RPKM 17.2), liver (RPKM 8.4) and 15 other tissues See more
    Orthologs
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    Genomic context

    See AJUBA in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (22971177..22982551, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17171795..17183169, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23440386..23451760, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5596 Neighboring gene tRNA-Arg (anticodon ACG) 1-3 Neighboring gene PRMT5 divergent transcript Neighboring gene HAUS augmin like complex subunit 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8155 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:23426503-23427082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23427083-23427661 Neighboring gene microRNA 4707 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:23444107-23444607 Neighboring gene Sharpr-MPRA regulatory region 809 Neighboring gene uncharacterized LOC124903287 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:23450809-23451774 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:23451775-23452740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5597 Neighboring gene AJUBA divergent transcript Neighboring gene chromosome 14 open reading frame 93 Neighboring gene uncharacterized LOC124903286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5598 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:23477153-23477713

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (27 hits/1271 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC15563

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding  
    enables alpha-catenin binding PubMed 
    enables chromatin binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables protein kinase activator activity  
    enables transcription corepressor activity  
    enables transcription corepressor activity PubMed 
    Process Evidence Code Pubs
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
    involved_in cytoskeleton organization  
    involved_in focal adhesion assembly  
    involved_in glycerophospholipid biosynthetic process  
    involved_in lamellipodium assembly  
    involved_in miRNA-mediated gene silencing by inhibition of translation PubMed 
    acts_upstream_of_or_within miRNA-mediated post-transcriptional gene silencing PubMed 
    involved_in negative regulation of hippo signaling  
    involved_in negative regulation of hippo signaling PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    acts_upstream_of_or_within positive regulation of protein-containing complex assembly PubMed 
    involved_in protein localization  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of cell migration  
    involved_in regulation of cellular response to hypoxia PubMed 
    involved_in response to hypoxia  
    involved_in response to hypoxia PubMed 
    involved_in wound healing, spreading of epidermal cells  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in P-body  
    located_in P-body PubMed 
    is_active_in adherens junction  
    located_in cell-cell junction PubMed 
    located_in centrosome  
    located_in cytosol  
    located_in cytosol  
    located_in focal adhesion  
    located_in lamellipodium  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in plasma membrane  
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    LIM domain-containing protein ajuba
    Names
    jub, ajuba homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289097.2 → NP_001276026.1  LIM domain-containing protein ajuba isoform 3

      See identical proteins and their annotated locations for NP_001276026.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA909473, AL132780, BC034968, BX109281
      UniProtKB/Swiss-Prot
      Q96IF1
    2. NM_032876.6 → NP_116265.1  LIM domain-containing protein ajuba isoform 1

      See identical proteins and their annotated locations for NP_116265.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL132780
      Consensus CDS
      CCDS9581.1
      UniProtKB/Swiss-Prot
      A8MX18, D3DS37, Q96IF1
      Related
      ENSP00000262713.2, ENST00000262713.7
      Conserved Domains (4) summary
      PHA03418
      Location:18 → 103
      PHA03418; hypothetical E4 protein; Provisional
      cd09352
      Location:338 → 391
      LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins
      cd09355
      Location:403 → 455
      LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins
      cd09438
      Location:463 → 524
      LIM3_Ajuba_like; The third LIM domain of Ajuba-like proteins
    3. NM_198086.3 → NP_932352.1  LIM domain-containing protein ajuba isoform 2

      See identical proteins and their annotated locations for NP_932352.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AL132780
      Consensus CDS
      CCDS9582.1
      UniProtKB/Swiss-Prot
      Q96IF1
      Related
      ENSP00000380543.3, ENST00000397388.7
      Conserved Domains (1) summary
      cl02475
      Location:46 → 107
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      22971177..22982551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      17171795..17183169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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