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    DEFB131A defensin beta 131A [ Homo sapiens (human) ]

    Gene ID: 644414, updated on 10-Dec-2024

    Summary

    Official Symbol
    DEFB131Aprovided by HGNC
    Official Full Name
    defensin beta 131Aprovided by HGNC
    Primary source
    HGNC:HGNC:18108
    See related
    Ensembl:ENSG00000186146 AllianceGenome:HGNC:18108
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DEFB-31; DEFB131
    Summary
    Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 4p16. [provided by RefSeq, Nov 2014]
    Expression
    Biased expression in duodenum (RPKM 4.4), small intestine (RPKM 1.1) and 1 other tissue See more
    Orthologs
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    Genomic context

    See DEFB131A in Genome Data Viewer
    Location:
    4p16.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (9444414..9450666)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (9464954..9471340)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (9446140..9452392)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 153 Neighboring gene defensin beta 130D (pseudogene) Neighboring gene olfactory receptor family 7 subfamily E member 86 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 84 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of defensin, beta 131 (DEFB131) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    beta-defensin 131A
    Names
    beta-defensin 131
    beta-defensin 31
    defensin beta 131
    defensin, beta 31

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040448.3NP_001035538.2  beta-defensin 131A precursor

      See identical proteins and their annotated locations for NP_001035538.2

      Status: REVIEWED

      Source sequence(s)
      AC116655, AF529414
      Consensus CDS
      CCDS43213.1
      UniProtKB/Swiss-Prot
      P59861
      Related
      ENSP00000335538.1, ENST00000334879.2
      Conserved Domains (1) summary
      pfam13841
      Location:2857
      Defensin_beta_2; Beta defensin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      9444414..9450666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      9464954..9471340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)