FTX FTX transcript, XIST regulator [Homo sapiens (human)] - Gene

Summary

Official Symbol: FTXprovided by HGNC
Official Full Name: FTX transcript, XIST regulatorprovided by HGNC
Primary source: HGNC:HGNC:37190
See related: Ensembl:ENSG00000230590 MIM:300936; AllianceGenome:HGNC:37190
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LINC00182; MIR374AHG; NCRNA00182
Summary: This gene is located upstream of XIST, within the X-inactivation center (XIC). It produces a spliced long non-coding RNA that is thought to positively regulate the expression of XIST, which is essential for the initiation and spread of X-inactivation. [provided by RefSeq, May 2015]
Expression: Ubiquitous expression in ovary (RPKM 3.1), thyroid (RPKM 2.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq13.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (74028136..74293574, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (72461681..72727079, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (73247971..73513409, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanism of LncRNA FTX regulates nephroblastoma progression through MiR-215-5p/PI3K/AKT axis.
Title: Mechanism of LncRNA FTX regulates nephroblastoma progression through MiR-215-5p/PI3K/AKT axis.
Quantitative Proteomics Analysis Reveals the Potential Role of lncRNA FTX in Endothelial Cells.
Title: Quantitative Proteomics Analysis Reveals the Potential Role of lncRNA FTX in Endothelial Cells.
Long noncoding RNA FTX promotes epithelial-mesenchymal transition of epithelial ovarian cancer through modulating miR-7515/TPD52 and activating Met/Akt/mTOR.
Title: Long noncoding RNA FTX promotes epithelial-mesenchymal transition of epithelial ovarian cancer through modulating miR-7515/TPD52 and activating Met/Akt/mTOR.
Emerging roles of long non-coding RNA FTX in human disorders.
Title: Emerging roles of long non-coding RNA FTX in human disorders.
The pluripotent factor OCT4A enhances the self-renewal of human dental pulp stem cells by targeting lncRNA FTX in an LPS-induced inflammatory microenvironment.
Title: The pluripotent factor OCT4A enhances the self-renewal of human dental pulp stem cells by targeting lncRNA FTX in an LPS-induced inflammatory microenvironment.
Overexpressed lncRNA FTX promotes the cell viability, proliferation, migration and invasion of renal cell carcinoma via FTX/miR4429/UBE2C axis.
Title: Overexpressed lncRNA FTX promotes the cell viability, proliferation, migration and invasion of renal cell carcinoma via FTX/miR‑4429/UBE2C axis.
Prognostic significance of long non-coding RNA five prime to XIST in various cancers.
Title: Prognostic significance of long non-coding RNA five prime to XIST in various cancers.
Long non-coding RNA (lncRNA) five prime to Xist (FTX) promotes retinoblastoma progression by regulating the microRNA-320a/with-no-lysine kinases 1 (WNK1) axis.
Title: Long non-coding RNA (lncRNA) five prime to Xist (FTX) promotes retinoblastoma progression by regulating the microRNA-320a/with-no-lysine kinases 1 (WNK1) axis.
Long non-coding RNA FTX predicts a poor prognosis of human cancers: a meta-analysis.
Title: Long non-coding RNA FTX predicts a poor prognosis of human cancers: a meta-analysis.
The Function of LncRNA FTX in Several Common Cancers.
Title: The Function of LncRNA FTX in Several Common Cancers.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DXS8361 (e-PCR)
- UniSTS:82185

DXS8066 (e-PCR)
- UniSTS:7438

RH46387 (e-PCR)
- UniSTS:50448

G31455 (e-PCR)
- UniSTS:76072

D8S2279 (e-PCR)
- UniSTS:473907

DXS7030E (e-PCR)
- UniSTS:98870

DXS8060 (e-PCR), detects polymorphism
- UniSTS:24132

DXS7025E (e-PCR)
- UniSTS:22601

DXS1103E (e-PCR)
- UniSTS:147786

G32744 (e-PCR)
- UniSTS:117325

SHGC-33546 (e-PCR)
- UniSTS:22102

DXS7741 (e-PCR)
- UniSTS:19293

RH65903 (e-PCR)
- UniSTS:81246

DXS1680 (e-PCR)
- UniSTS:99433

RH64973 (e-PCR)
- UniSTS:86378

DXS1103E (e-PCR)
- UniSTS:99209

WIAF-2551 (e-PCR)
- UniSTS:36491

RH68565 (e-PCR)
- UniSTS:47764

RH36104 (e-PCR)
- UniSTS:79265

SHGC-32393 (e-PCR)
- UniSTS:63654

RH18206 (e-PCR)
- UniSTS:75182

AFM352tf5 (e-PCR)
- UniSTS:28093

A009P32 (e-PCR)
- UniSTS:39891

SHGC-33275 (e-PCR)
- UniSTS:45786

SHGC-34600 (e-PCR)
- UniSTS:68580

G31131 (e-PCR)
- UniSTS:5610

DXS1166 (e-PCR)
- UniSTS:99053

DXS1103E (e-PCR)
- UniSTS:42750

Other Names

FTX transcript, XIST regulator (non-protein coding)
five prime to XIST
mir-374a-545 cluster host gene (non-protein coding)

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.