U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Mpzl2 myelin protein zero-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 14012, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mpzl2provided by MGI
    Official Full Name
    myelin protein zero-like 2provided by MGI
    Primary source
    MGI:MGI:1289160
    See related
    Ensembl:ENSMUSG00000032092 AllianceGenome:MGI:1289160
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eva; Eva1
    Summary
    Acts upstream of or within T cell differentiation in thymus and cell-cell adhesion. Located in plasma membrane. Is expressed in several structures, including branchial arch; epithelium; genitourinary system; gut; and hemolymphoid system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 111. Orthologous to human MPZL2 (myelin protein zero like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 17.0), placenta adult (RPKM 12.4) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mpzl2 in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44951595..44965341)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45042344..45054043)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44794321-44794504 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44794585-44794829 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44804746-44804978 Neighboring gene CD3 antigen, delta polypeptide Neighboring gene CD3 antigen, epsilon polypeptide Neighboring gene STARR-seq mESC enhancer starr_23989 Neighboring gene STARR-positive B cell enhancer mm9_chr9:44849180-44849480 Neighboring gene STARR-seq mESC enhancer starr_23990 Neighboring gene myelin protein zero-like 3 Neighboring gene junction adhesion molecule like Neighboring gene predicted gene 10684

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    myelin protein zero-like protein 2
    Names
    epithelial V-like antigen 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357727.1NP_001344656.1  myelin protein zero-like protein 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC122305
      Consensus CDS
      CCDS23126.1
      UniProtKB/Swiss-Prot
      O70255
      UniProtKB/TrEMBL
      F6RG10, Q3TLS6
      Conserved Domains (1) summary
      cd05880
      Location:28142
      Ig_EVA1; Immunoglobulin (Ig)-like domain of epithelial V-like antigen 1 (EVA)
    2. NM_007962.4NP_031988.2  myelin protein zero-like protein 2 precursor

      See identical proteins and their annotated locations for NP_031988.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK032788, AK167263, BY230064, BY387940
      Consensus CDS
      CCDS23126.1
      UniProtKB/Swiss-Prot
      O70255
      UniProtKB/TrEMBL
      F6RG10, Q3TLS6
      Related
      ENSMUSP00000034600.5, ENSMUST00000034600.5
      Conserved Domains (1) summary
      cd05880
      Location:28142
      Ig_EVA1; Immunoglobulin (Ig)-like domain of epithelial V-like antigen 1 (EVA)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44951595..44965341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154609.1XP_036010502.1  myelin protein zero-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A1L1STN6
      Related
      ENSMUSP00000150395.2, ENSMUST00000217097.2
      Conserved Domains (2) summary
      cd00096
      Location:26
      Ig; Ig strand C" [structural motif]
      cl11960
      Location:262
      Ig; Immunoglobulin domain
    External link. Please review our privacy policy.