Pyy peptide YY [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pyyprovided by MGI
Official Full Name: peptide YYprovided by MGI
Primary source: MGI:MGI:99924
See related: Ensembl:ENSMUSG00000017311 AllianceGenome:MGI:99924
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables neuropeptide hormone activity. Acts upstream of or within eating behavior. Located in extracellular space. Is expressed in brain and gut. Orthologous to several human genes including PYY (peptide YY). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 340.5), large intestine adult (RPKM 63.1) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 65.48 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (101997502..101998658, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (102106676..102107832, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells.
Title: RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells.
The PYY/Y2R-deficient male mouse is not protected from bone loss due to Roux-en-Y gastric bypass.
Title: The PYY/Y2R-deficient male mouse is not protected from bone loss due to Roux-en-Y gastric bypass.
Roux-en-Y Gastrointestinal Bypass Promotes Activation of TGR5 and Peptide YY.
Title: Roux-en-Y Gastrointestinal Bypass Promotes Activation of TGR5 and Peptide YY.
Lack of peptide YY signaling in mice disturbs gut microbiome composition in response to high-fat diet.
Title: Lack of peptide YY signaling in mice disturbs gut microbiome composition in response to high-fat diet.
Free Fatty Acid-Induced Peptide YY Expression Is Dependent on TG Synthesis Rate and Xbp1 Splicing.
Title: Free Fatty Acid-Induced Peptide YY Expression Is Dependent on TG Synthesis Rate and Xbp1 Splicing.
PYY is a negative regulator of bone mass and strength.
Title: PYY is a negative regulator of bone mass and strength.
It was concluded that PYY signaling through Y2R is not required for the normal appetite-suppressing and body weight-lowering effects of Roux-en-Y gastric bypass in this global knockout mouse model.
Title: The PYY/Y2R-Deficient Mouse Responds Normally to High-Fat Diet and Gastric Bypass Surgery.
The reduction in goal-directed behavior is associated with dysfunction of D2R signaling via increased peripheral PYY.
Title: Peptide YY Causes Apathy-Like Behavior via the Dopamine D2 Receptor in Repeated Water-Immersed Mice.
Data show that peptide YY (PYY) mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets.
Title: Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets.
These results indicate that endogenous PYY has a hypoalgesic effect on somatic thermal and visceral chemical pain. The effect on visceral pain seems to be mediated by peripheral Y2 receptors.
Title: Visceral hyperalgesia caused by peptide YY deletion and Y2 receptor antagonism.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (7) 1 citation

General gene information

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Markers

RH130253 (e-PCR)
- UniSTS:213540

Pyy (e-PCR), detects polymorphism
- UniSTS:516150

Pyy (e-PCR), detects polymorphism
- UniSTS:516151

RH136581 (e-PCR)
- UniSTS:210561

Pyy (e-PCR), detects polymorphism
- UniSTS:525270

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuropeptide Y receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within eating behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of response to food	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptide YY

Names: Peptide tyrosine tyrosine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.