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    Lrrc25 leucine rich repeat containing 25 [ Mus musculus (house mouse) ]

    Gene ID: 211228, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc25provided by MGI
    Official Full Name
    leucine rich repeat containing 25provided by MGI
    Primary source
    MGI:MGI:2445284
    See related
    Ensembl:ENSMUSG00000049988 AllianceGenome:MGI:2445284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mapa
    Summary
    Predicted to be located in cytosol; endoplasmic reticulum; and microtubule cytoskeleton. Orthologous to human LRRC25 (leucine rich repeat containing 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 29.7), mammary gland adult (RPKM 15.4) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc25 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71068810..71073501)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70616844..70620850)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1369 Neighboring gene myo-inositol 1-phosphate synthase A1 Neighboring gene single stranded DNA binding protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E3777 Neighboring gene STARR-positive B cell enhancer ABC_E3778 Neighboring gene STARR-positive B cell enhancer ABC_E3779 Neighboring gene STARR-positive B cell enhancer ABC_E6645 Neighboring gene STARR-seq mESC enhancer starr_21778 Neighboring gene growth differentiation factor 15 Neighboring gene predicted gene, 34154

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of LRRC25 accelerates pathological cardiac hypertrophy through promoting fibrosis and inflammation regulated by TGF-β1. Zhang X, et al. Biochem Biophys Res Commun, 2018 Nov 17. PMID 30340835
    2. Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. Rissoan MC, et al. Blood, 2002 Nov 1. PMID 12384430
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LRRC25 as a critical molecular switch whose down-regulation resulted in cardiac hypertrophy in a TGF-beta1- and NF-kappaB-dependent manner.
      Title: Loss of LRRC25 accelerates pathological cardiac hypertrophy through promoting fibrosis and inflammation regulated by TGF-β1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 25
    Names
    monocyte and plasmacytoid activated molecule
    monocyte and plasmacytoid-activated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153074.4 → NP_694714.1  leucine-rich repeat-containing protein 25 precursor

      See identical proteins and their annotated locations for NP_694714.1

      Status: VALIDATED

      Source sequence(s)
      AC157774
      Consensus CDS
      CCDS22375.1
      UniProtKB/Swiss-Prot
      Q3TAD5, Q8K1T1
      UniProtKB/TrEMBL
      B9EHD0
      Related
      ENSMUSP00000049686.4, ENSMUST00000052437.6
      Conserved Domains (2) summary
      sd00031
      Location:68 → 90
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:65 → 105
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71068810..71073501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153854.1 → XP_036009747.1  leucine-rich repeat-containing protein 25 isoform X1

      UniProtKB/Swiss-Prot
      Q3TAD5, Q8K1T1
      UniProtKB/TrEMBL
      B9EHD0
      Conserved Domains (2) summary
      sd00031
      Location:68 → 90
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:65 → 105
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1T1.1 GenPept UniProtKB/Swiss-Prot:Q8K1T1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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