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    Cox8b cytochrome c oxidase subunit 8B [ Mus musculus (house mouse) ]

    Gene ID: 12869, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cox8bprovided by MGI
    Official Full Name
    cytochrome c oxidase subunit 8Bprovided by MGI
    Primary source
    MGI:MGI:105958
    See related
    Ensembl:ENSMUSG00000025488 AllianceGenome:MGI:105958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cox8h; CoxVIII-H
    Summary
    Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Is expressed in brown fat; heart; and tongue. Orthologous to human COX8BP (cytochrome c oxidase subunit 8B, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in heart adult (RPKM 359.9), adrenal adult (RPKM 147.9) and 4 other tissues See more
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    Genomic context

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    See Cox8b in Genome Data Viewer
    Location:
    7 F5; 7 86.11 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140478855..140480359, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140898942..140900446, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIC8 guanine nucleotide exchange factor A Neighboring gene sirtuin 3 Neighboring gene STARR-positive B cell enhancer ABC_E9304 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8220 Neighboring gene cDNA sequence BC023486 Neighboring gene NLR family, pyrin domain containing 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence of the cDNA for the heart/muscle isoform of mouse cytochrome c oxidase subunit VIII. Hegeman AD, et al. Biochim Biophys Acta, 1995 Apr 4. PMID 7711081
    2. The gene encoding the heart/muscle isoform of cytochrome c oxidase subunit VIII maps to mouse chromosome 7. Makris GJ, et al. Mamm Genome, 1997 Jun. PMID 9166597
    3. Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle. Bachman NJ, et al. Genomics, 1997 May 15. PMID 9177785
    4. Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse. Fonseca TL, et al. Endocrinology, 2022 May 1. PMID 35238380, Free PMC Article
    5. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Tseng YH, et al. Nature, 2008 Aug 21. PMID 18719589, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107661

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 8B, mitochondrial
    Names
    COX VIII-H
    cytochrome c oxidase polypeptide VIII-heart
    cytochrome c oxidase subunit 8-1
    cytochrome c oxidase subunit 8H
    cytochrome c oxidase subunit VIII-H
    cytochrome c oxidase subunit VIIIb
    NP_031777.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007751.3 → NP_031777.1  cytochrome c oxidase subunit 8B, mitochondrial precursor

      See identical proteins and their annotated locations for NP_031777.1

      Status: VALIDATED

      Source sequence(s)
      AA511205, BE626379
      Consensus CDS
      CCDS21991.1
      UniProtKB/Swiss-Prot
      P48772
      UniProtKB/TrEMBL
      Q545U6
      Related
      ENSMUSP00000026561.9, ENSMUST00000026561.10
      Conserved Domains (1) summary
      pfam02285
      Location:26 → 66
      COX8; Cytochrome oxidase c subunit VIII

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140478855..140480359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48772.1 GenPept UniProtKB/Swiss-Prot:P48772

    Gene LinkOut

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