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    Lilra6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 [ Mus musculus (house mouse) ]

    Gene ID: 18726, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lilra6provided by MGI
    Official Full Name
    leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6provided by MGI
    Primary source
    MGI:MGI:1195969
    See related
    Ensembl:ENSMUSG00000030427 AllianceGenome:MGI:1195969
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    7M1; Pira3
    Summary
    Predicted to enable several functions, including IgM binding activity; coreceptor activity; and inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immune response-regulating signaling pathway. Predicted to be part of Fc-epsilon receptor I complex. Predicted to be active in plasma membrane. Is expressed in embryo. Orthologous to several human genes including LILRA4 (leukocyte immunoglobulin like receptor A4); LILRA6 (leukocyte immunoglobulin like receptor A6); and LILRB3 (leukocyte immunoglobulin like receptor B3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 11.9), mammary gland adult (RPKM 6.3) and 14 other tissues See more
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    Genomic context

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    See Lilra6 in Genome Data Viewer
    Location:
    7 A1; 7 2.25 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3911276..3918569, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3908277..3915571, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 10693 Neighboring gene paired-Ig-like receptor A12 Neighboring gene RIKEN cDNA 1700095K22 gene Neighboring gene STARR-seq mESC enhancer starr_17915 Neighboring gene predicted gene 7363

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice. Kelsey L, et al. PLoS Genet, 2013. PMID 23874215, Free PMC Article
    2. A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Kubagawa H, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144225, Free PMC Article
    3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables IgM binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables coreceptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inhibitory MHC class I receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Fc-epsilon receptor I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    paired-Ig-like receptor A3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011090.2 → NP_035220.2  paired-Ig-like receptor A3 precursor

      See identical proteins and their annotated locations for NP_035220.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes a functional protein.
      Source sequence(s)
      AK152898, BB665966, BC127613
      Consensus CDS
      CCDS20728.1
      UniProtKB/TrEMBL
      A0A0B4J1F3, A2NTK0
      Related
      ENSMUSP00000042636.9, ENSMUST00000038176.15
      Conserved Domains (2) summary
      smart00410
      Location:529 → 617
      IG_like; Immunoglobulin like
      cl11960
      Location:225 → 315
      Ig; Immunoglobulin domain

    RNA

    1. NR_028115.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional segment in the 5' region, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, and unlikely to make a functional protein.
      Source sequence(s)
      AK152898, BC119598
      Related
      ENSMUST00000206077.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      3911276..3918569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539630.5 → XP_006539693.1  paired-Ig-like receptor A3 isoform X2

      See identical proteins and their annotated locations for XP_006539693.1

      UniProtKB/TrEMBL
      D3Z674
      Conserved Domains (1) summary
      cl11960
      Location:225 → 315
      Ig; Immunoglobulin domain

    2. XM_006539632.5 → XP_006539695.1  paired-Ig-like receptor A3 isoform X3

      UniProtKB/TrEMBL
      A2NTK0
      Conserved Domains (1) summary
      cl11960
      Location:225 → 315
      Ig; Immunoglobulin domain

    3. XM_036152786.1 → XP_036008679.1  paired-Ig-like receptor A3 isoform X4

      UniProtKB/TrEMBL
      A2NTK2
      Conserved Domains (2) summary
      cd00096
      Location:124 → 128
      Ig; Ig strand A [structural motif]
      cl11960
      Location:123 → 219
      Ig; Immunoglobulin domain

    4. XM_006539629.4 → XP_006539692.1  paired-Ig-like receptor A3 isoform X1

      UniProtKB/TrEMBL
      E9Q6M9
      Conserved Domains (1) summary
      cl11960
      Location:123 → 219
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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