U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Coro1c coronin, actin binding protein 1C [ Mus musculus (house mouse) ]

    Gene ID: 23790, updated on 9-Dec-2024

    Summary

    Official Symbol
    Coro1cprovided by MGI
    Official Full Name
    coronin, actin binding protein 1Cprovided by MGI
    Primary source
    MGI:MGI:1345964
    See related
    Ensembl:ENSMUSG00000004530 AllianceGenome:MGI:1345964
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CRN2
    Summary
    Enables small GTPase binding activity. Involved in several processes, including activation of GTPase activity; regulation of fibroblast migration; and regulation of ruffle assembly. Acts upstream of or within corpus callosum development and ventricular system development. Located in cytoskeleton. Part of flotillin complex. Is expressed in several structures, including brain; dorsal root ganglion; genitourinary system; liver; and spleen. Orthologous to human CORO1C (coronin 1C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 69.2), colon adult (RPKM 57.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Coro1c in Genome Data Viewer
    Location:
    5 F; 5 55.64 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (113980500..114046767, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (113842439..113908706, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:114275604-114275870 Neighboring gene protein LLP homolog Neighboring gene STARR-positive B cell enhancer ABC_E1686 Neighboring gene selectin, platelet (p-selectin) ligand Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:114282525-114282873 Neighboring gene STARR-seq mESC enhancer starr_14053 Neighboring gene predicted gene, 52824 Neighboring gene predicted gene, 42005 Neighboring gene STARR-positive B cell enhancer ABC_E4779 Neighboring gene predicted gene, 22056 Neighboring gene slingshot protein phosphatase 1 Neighboring gene STARR-seq mESC enhancer starr_14062 Neighboring gene predicted gene, 52826

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

    General gene information

    Clone Names

    • MGC102522

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding  
    enables actin filament binding  
    enables actin filament binding  
    enables small GTPase binding PubMed 
    Items 1 - 25 of 37
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cortical patch assembly PubMed 
    acts_upstream_of_or_within actin cytoskeleton organization PubMed 
    involved_in actin filament organization  
    involved_in activation of GTPase activity PubMed 
    involved_in activation of GTPase activity PubMed 
    acts_upstream_of_or_within corpus callosum development PubMed 
    involved_in endosomal transport  
    involved_in endosomal transport  
    involved_in endosome fission  
    involved_in endosome fission  
    involved_in endosome membrane tubulation  
    involved_in endosome membrane tubulation  
    involved_in establishment of protein localization PubMed 
    involved_in establishment of protein localization PubMed 
    involved_in membrane fission  
    involved_in membrane fission  
    involved_in negative regulation of epithelial cell migration  
    involved_in negative regulation of epithelial cell migration  
    involved_in negative regulation of focal adhesion assembly  
    involved_in negative regulation of focal adhesion assembly  
    involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation  
    involved_in negative regulation of protein phosphorylation  
    involved_in negative regulation of substrate adhesion-dependent cell spreading  
    involved_in negative regulation of substrate adhesion-dependent cell spreading  
    involved_in neural crest cell migration  
    involved_in neural crest cell migration  
    involved_in neural crest cell migration  
    acts_upstream_of_or_within phagocytosis PubMed 
    involved_in positive regulation of lamellipodium morphogenesis  
    involved_in positive regulation of lamellipodium morphogenesis  
    involved_in regulation of epithelial cell migration  
    involved_in regulation of fibroblast migration PubMed 
    involved_in regulation of focal adhesion assembly  
    involved_in regulation of protein phosphorylation  
    involved_in regulation of ruffle assembly PubMed 
    involved_in regulation of substrate adhesion-dependent cell spreading  
    acts_upstream_of_or_within ventricular system development PubMed 
    Items 1 - 25 of 37
    Component Evidence Code Pubs
    located_in actin cytoskeleton  
    located_in actin cytoskeleton  
    located_in cell cortex  
    located_in cytoskeleton PubMed 
    located_in cytoskeleton PubMed 
    located_in endosome membrane  
    located_in endosome membrane  
    part_of flotillin complex PubMed 
    located_in lamellipodium  
    located_in lamellipodium  
    located_in lateral plasma membrane  
    located_in lateral plasma membrane  
    located_in ruffle membrane  
    colocalizes_with vesicle  

    General protein information

    Preferred Names
    coronin-1C
    Names
    coronin 1c
    coronin-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011779.3NP_035909.2  coronin-1C

      See identical proteins and their annotated locations for NP_035909.2

      Status: PROVISIONAL

      Source sequence(s)
      AK082986
      Consensus CDS
      CCDS19555.1
      UniProtKB/Swiss-Prot
      Q499X7, Q8VCQ5, Q9WUM4
      UniProtKB/TrEMBL
      Q3TF74, Q5PPQ7
      Related
      ENSMUSP00000004646.7, ENSMUST00000004646.13
      Conserved Domains (6) summary
      PTZ00421
      Location:8471
      PTZ00421; coronin; Provisional
      pfam05873
      Location:429474
      Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)
      pfam08953
      Location:663
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:343385
      WD40_4; Type of WD40 repeat
      sd00039
      Location:3678
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:75300
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      113980500..114046767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.