Prip prip [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pripprovided by FlyBase
Official Full Name: pripprovided by FlyBase
Primary source: FLYBASE:FBgn0033635
Locus tag: Dmel_CG7777
See related: AllianceGenome:FB:FBgn0033635
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Aqp7777; CG7777; Dmel\CG7777
Summary: Enables water channel activity. Involved in water transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including adult Malpighian tubule stellate cell of main segment; adult head; epithelium; ganglia; and germline cell. Human ortholog(s) of this gene implicated in Bothnian type palmoplantar keratoderma; nephrogenic diabetes insipidus; and nephrogenic diabetes insipidus type 2. Orthologous to human AQP1 (aquaporin 1 (Colton blood group)); AQP2 (aquaporin 2); and AQP5 (aquaporin 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 47F12-47F13; 2-64 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (11436243..11442216)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7323748..7329721)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables channel activity	IEA Inferred from Electronic Annotation more info
enables channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables water channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in water transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prip

Names: CG7777-PA; CG7777-PB; CG7777-PC; CG7777-PD; Prip-PA; Prip-PB; Prip-PC; Prip-PD; aquaporin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

11436243..11442216

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136842.4 → NP_610686.1 prip, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610686.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95TS2

Related

FBpp0087235

Conserved Domains (1) summary

cl00200
Location:12 → 226

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
NM_001259337.2 → NP_001246266.1 prip, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246266.1

Status: REVIEWED

UniProtKB/TrEMBL

D3DMU9

Conserved Domains (1) summary

cl00200
Location:12 → 226

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
NM_001299388.1 → NP_001286317.1 prip, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286317.1

Status: REVIEWED

UniProtKB/TrEMBL

J7K3P9

Conserved Domains (1) summary

cl00200
Location:12 → 226

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
NM_165834.3 → NP_725052.1 prip, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725052.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z8L8

Related

FBpp0087236

Conserved Domains (1) summary

cl00200
Location:12 → 226

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...