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    Rasef RAS and EF hand domain containing [ Mus musculus (house mouse) ]

    Gene ID: 242505, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rasefprovided by MGI
    Official Full Name
    RAS and EF hand domain containingprovided by MGI
    Primary source
    MGI:MGI:2448565
    See related
    Ensembl:ENSMUSG00000043003 AllianceGenome:MGI:2448565
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RAB45
    Summary
    Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and identical protein binding activity. Predicted to be involved in vesicle-mediated transport. Predicted to be active in cytosol and perinuclear region of cytoplasm. Orthologous to human RASEF (RAS and EF-hand domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 11.0), stomach adult (RPKM 6.6) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rasef in Genome Data Viewer
    Location:
    4 C3; 4 36.06 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (73632814..73709382, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (73714577..73791236, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Myb/SANT DNA binding domain containing 5 family member 2 Neighboring gene Myb/SANT DNA binding domain containing 5 family member 1 Neighboring gene predicted gene 11240 Neighboring gene Myb/SANT DNA binding domain containing 5 family member 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RASEF/Rab45 regulates the formation and sorting of zymogen granules and secretion of digestive enzymes by pancreatic acinar cells. Sato K, et al. Biochim Biophys Acta Mol Basis Dis, 2024 Oct. PMID 38901651
    2. RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer. Oshita H, et al. Mol Cancer Res, 2013 Aug. PMID 23686708
    3. Testis-Specific GTPase (TSG): An oligomeric protein. Kumar S, et al. BMC Genomics, 2016 Oct 10. PMID 27724860, Free PMC Article
    4. CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice. Oyama Y, et al. Asian J Androl, 2022 May-Jun. PMID 34290169, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RASEF/Rab45 regulates the formation and sorting of zymogen granules and secretion of digestive enzymes by pancreatic acinar cells.
      Title: RASEF/Rab45 regulates the formation and sorting of zymogen granules and secretion of digestive enzymes by pancreatic acinar cells.
    2. Results show elevated RASEF promoted cell growth via enhanced ERK signaling and is associated with poor prognosis of non-small cell lung carcinoma (NSCLC)
      Title: RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras and EF-hand domain-containing protein homolog
    Names
    testis-specific GTPase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017427.1 → NP_001017427.1  ras and EF-hand domain-containing protein homolog isoform 1

      See identical proteins and their annotated locations for NP_001017427.1

      Status: VALIDATED

      Source sequence(s)
      AK132691, BB616033
      Consensus CDS
      CCDS18281.1
      UniProtKB/Swiss-Prot
      B2RQ59, Q5RI75, Q5RI76
      Related
      ENSMUSP00000062771.7, ENSMUST00000058292.13
      Conserved Domains (2) summary
      cd00154
      Location:429 → 593
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      COG1196
      Location:27 → 258
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001404961.1 → NP_001391890.1  ras and EF-hand domain-containing protein homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX294159
      UniProtKB/TrEMBL
      A0A1Y7VIT3
      Related
      ENSMUSP00000152127.2, ENSMUST00000222414.2

    3. NM_001404962.1 → NP_001391891.1  ras and EF-hand domain-containing protein homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX294159
      Related
      ENSMUSP00000099901.3, ENSMUST00000102837.3

    4. NM_001404963.1 → NP_001391892.1  ras and EF-hand domain-containing protein homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      BX294159
      UniProtKB/TrEMBL
      A0A1D8RIR4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      73632814..73709382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320201.2 → XP_017175690.1  ras and EF-hand domain-containing protein homolog isoform X3

      UniProtKB/Swiss-Prot
      B2RQ59, Q5RI75, Q5RI76
      Conserved Domains (2) summary
      cd00154
      Location:429 → 593
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      COG1196
      Location:27 → 258
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_006537927.3 → XP_006537990.1  ras and EF-hand domain-containing protein homolog isoform X2

      See identical proteins and their annotated locations for XP_006537990.1

      UniProtKB/TrEMBL
      A0A1D8RIR4
      Conserved Domains (2) summary
      cd00154
      Location:332 → 496
      Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)
      COG1196
      Location:9 → 154
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RI75.1 GenPept UniProtKB/Swiss-Prot:Q5RI75

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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