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    CalpA Calpain-A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37232, updated on 17-Dec-2024

    Summary

    Official Symbol
    CalpAprovided by FlyBase
    Official Full Name
    Calpain-Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0012051
    Locus tag
    Dmel_CG7563
    See related
    AllianceGenome:FB:FBgn0012051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    calpA; CG18152; CG7563; Dmel\CG7563; EST C
    Summary
    Enables calcium-dependent cysteine-type endopeptidase activity. Involved in several processes, including determination of adult lifespan; neuron remodeling; and protein autoprocessing. Located in actin cytoskeleton and neuronal cell body. Is active in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including adult central nervous system; adult head; gut section; head epidermis primordium; and neuromere. Used to study intellectual disability and obesity. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; muscular dystrophy; and stomach cancer. Orthologous to several human genes including CAPN9 (calpain 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See CalpA in Genome Data Viewer
    Location:
    56D5-56D5; 2-89 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19425113..19430564)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15312618..15318069)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene hu li tai shao Neighboring gene transfer RNA:Valine-AAC 2-1 Neighboring gene transfer RNA:Valine-AAC 2-2 Neighboring gene Focal adhesion kinase Neighboring gene Spt5

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cuticle development PubMed 
    involved_in defense response to fungus PubMed 
    involved_in determination of adult lifespan PubMed 
    involved_in dorsal/ventral pattern formation PubMed 
    involved_in larval locomotory behavior PubMed 
    involved_in myoblast fusion PubMed 
    involved_in neuron remodeling PubMed 
    involved_in neuron remodeling PubMed 
    involved_in protein autoprocessing PubMed 
    involved_in proteolysis  
    involved_in proteolysis PubMed 
    involved_in proteolysis  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus PubMed 
    located_in actin cytoskeleton PubMed 
    is_active_in cytoplasm  
    is_active_in endoplasmic reticulum PubMed 
    located_in neuronal cell body PubMed 

    General protein information

    Preferred Names
    Calpain-A
    Names
    CG7563-PA
    CG7563-PB
    CG7563-PC
    CG7563-PD
    CalpA-PA
    CalpA-PB
    CalpA-PC
    CalpA-PD
    calpain
    calpain A
    calpain lacking calmodulin-like domain
    calpainA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19425113..19430564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299684.1 → NP_001286613.1  Calpain-A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG26
      Conserved Domains (3) summary
      cd00051
      Location:719 → 765
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00648
      Location:104 → 400
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:418 → 565
      Calpain_III; Calpain large subunit, domain III
    2. NM_001103908.2 → NP_001097378.1  Calpain-A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097378.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q11002, Q9V8U6, Q9V8U7
      UniProtKB/TrEMBL
      A8DYJ3
      Conserved Domains (3) summary
      cd00214
      Location:401 → 554
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16196
      Location:585 → 828
      EFh_PEF_CalpA_B; Penta-EF hand, calcium binding motifs, found in Drosophila melanogaster calpain-A (CalpA), calpain-B (CalpB), and similar proteins
      pfam00648
      Location:89 → 385
      Peptidase_C2; Calpain family cysteine protease
    3. NM_057699.5 → NP_477047.1  Calpain-A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477047.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q11002, Q9V8U6, Q9V8U7
      UniProtKB/TrEMBL
      A8DYJ3
      Related
      FBpp0085714
      Conserved Domains (3) summary
      cd00214
      Location:401 → 554
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      cd16196
      Location:585 → 828
      EFh_PEF_CalpA_B; Penta-EF hand, calcium binding motifs, found in Drosophila melanogaster calpain-A (CalpA), calpain-B (CalpB), and similar proteins
      pfam00648
      Location:89 → 385
      Peptidase_C2; Calpain family cysteine protease
    4. NM_057700.4 → NP_477048.1  Calpain-A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477048.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q11002
      Related
      FBpp0085715
      Conserved Domains (2) summary
      pfam00648
      Location:89 → 385
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:403 → 550
      Calpain_III; Calpain large subunit, domain III
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