Tmem241 transmembrane protein 241 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem241provided by MGI
Official Full Name: transmembrane protein 241provided by MGI
Primary source: MGI:MGI:2442435
See related: Ensembl:ENSMUSG00000049411 AllianceGenome:MGI:2442435
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6030446N20Rik
Summary: Predicted to enable GDP-mannose transmembrane transporter activity; UDP-N-acetylglucosamine transmembrane transporter activity; and antiporter activity. Predicted to be involved in GDP-mannose transmembrane transport and UDP-N-acetylglucosamine transmembrane transport. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Orthologous to human TMEM241 (transmembrane protein 241). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 5.98 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (12113193..12254604, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (11980119..12121570, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport.
Title: TMEM241 is a UDP-N-acetylglucosamine transporter required for M6P modification of NPC2 and cholesterol transport.
Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.
Title: Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Targeted (2)

General gene information

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Markers

D18Mit67 (e-PCR), detects polymorphism
- UniSTS:128282

D7Uwm10 (e-PCR)
- UniSTS:239402

D1S3688 (e-PCR)
- UniSTS:474266

NoName (e-PCR)
- UniSTS:237742

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GDP-mannose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-N-acetylglucosamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables UDP-N-acetylglucosamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables antiporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in GDP-mannose transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP-N-acetylglucosamine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in UDP-N-acetylglucosamine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: UDP-N-acetylglucosamine transporter TMEM241; transmembrane protein 241

Names: transmembrane protein C18orf45 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289666.1 → NP_001276595.1 UDP-N-acetylglucosamine transporter TMEM241 isoform 1

See identical proteins and their annotated locations for NP_001276595.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK038472, AK051727

Consensus CDS

CCDS84358.1

UniProtKB/Swiss-Prot

Q3UME2, Q8BQ16, Q8CAM4, Q8CAM9, Q8CD42

UniProtKB/TrEMBL

B2RPV5

Related

ENSMUSP00000147687.2, ENSMUST00000209859.2

Conserved Domains (1) summary

COG5070
Location:10 → 193

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
NM_001289667.1 → NP_001276596.1 UDP-N-acetylglucosamine transporter TMEM241 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This results in a shorter isoform (3) that has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK038472, AK051727, BC094382

UniProtKB/TrEMBL

A0A1B0GSM8
NM_178801.5 → NP_848916.2 UDP-N-acetylglucosamine transporter TMEM241 isoform 2

See identical proteins and their annotated locations for NP_848916.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. This results in a shorter isoform (2) that has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK038472, AK051727, BC094382

Consensus CDS

CCDS84359.1

UniProtKB/TrEMBL

B2RPV5

Related

ENSMUSP00000052001.8, ENSMUST00000055447.14

Conserved Domains (1) summary

COG5070
Location:10 → 193

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RNA

NR_110356.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK031517, AK038472, AK051727

Related

ENSMUST00000211298.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

12113193..12254604 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526053.5 → XP_006526116.1 transmembrane protein 241 isoform X5

UniProtKB/TrEMBL

B2RPV5

Conserved Domains (1) summary

COG5070
Location:122 → 243

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_006526056.5 → XP_006526119.1 transmembrane protein 241 isoform X8

UniProtKB/TrEMBL

B2RPV5

Conserved Domains (1) summary

COG5070
Location:122 → 243

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_011246964.4 → XP_011245266.1 transmembrane protein 241 isoform X7

See identical proteins and their annotated locations for XP_011245266.1

Conserved Domains (1) summary

COG5070
Location:104 → 243

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_006526055.5 → XP_006526118.1 transmembrane protein 241 isoform X7

See identical proteins and their annotated locations for XP_006526118.1

Conserved Domains (1) summary

COG5070
Location:104 → 243

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_030250518.2 → XP_030106378.1 transmembrane protein 241 isoform X17

UniProtKB/TrEMBL

B2RPV5

Conserved Domains (1) summary

COG5070
Location:10 → 167

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_036161196.1 → XP_036017089.1 transmembrane protein 241 isoform X25

Conserved Domains (1) summary

COG5070
Location:10 → 100

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_036161192.1 → XP_036017085.1 transmembrane protein 241 isoform X16

UniProtKB/TrEMBL

B2RPV5
XM_036161193.1 → XP_036017086.1 transmembrane protein 241 isoform X19

UniProtKB/TrEMBL

B2RPV5
XM_030250519.2 → XP_030106379.1 transmembrane protein 241 isoform X22

Conserved Domains (1) summary

COG5070
Location:10 → 193

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_036161191.1 → XP_036017084.1 transmembrane protein 241 isoform X13

UniProtKB/TrEMBL

B2RPV5
XM_011246967.4 → XP_011245269.1 transmembrane protein 241 isoform X18

Conserved Domains (1) summary

COG5070
Location:104 → 243

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_036161194.1 → XP_036017087.1 transmembrane protein 241 isoform X21

UniProtKB/TrEMBL

B2RPV5

Conserved Domains (1) summary

COG5070
Location:21 → 142

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_006526057.5 → XP_006526120.1 transmembrane protein 241 isoform X9

Conserved Domains (1) summary

COG5070
Location:104 → 243

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_006526059.5 → XP_006526122.1 transmembrane protein 241 isoform X11

Conserved Domains (1) summary

COG5070
Location:104 → 243

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_006526054.5 → XP_006526117.1 transmembrane protein 241 isoform X6

Conserved Domains (1) summary

COG5070
Location:104 → 243

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_006526051.5 → XP_006526114.1 transmembrane protein 241 isoform X1

Conserved Domains (1) summary

COG5070
Location:104 → 243

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_006526052.5 → XP_006526115.1 transmembrane protein 241 isoform X2

Conserved Domains (1) summary

COG5070
Location:104 → 243

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_006526060.5 → XP_006526123.1 transmembrane protein 241 isoform X14

Conserved Domains (1) summary

COG5070
Location:10 → 167

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_006526058.5 → XP_006526121.1 transmembrane protein 241 isoform X10

Conserved Domains (1) summary

COG5070
Location:10 → 193

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_036161190.1 → XP_036017083.1 transmembrane protein 241 isoform X4
XM_036161189.1 → XP_036017082.1 transmembrane protein 241 isoform X3
XM_011246966.4 → XP_011245268.1 transmembrane protein 241 isoform X15

Conserved Domains (1) summary

COG5070
Location:21 → 142

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_011246965.2 → XP_011245267.1 transmembrane protein 241 isoform X12

Conserved Domains (1) summary

COG5070
Location:53 → 192

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_030250520.2 → XP_030106380.1 transmembrane protein 241 isoform X26

Conserved Domains (1) summary

COG5070
Location:10 → 167

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_036161195.1 → XP_036017088.1 transmembrane protein 241 isoform X23

Related

ENSMUSP00000089709.5, ENSMUST00000092075.5

Conserved Domains (1) summary

COG5070
Location:10 → 193

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_006526063.5 → XP_006526126.1 transmembrane protein 241 isoform X20

Conserved Domains (1) summary

COG5070
Location:104 → 243

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
XM_011246968.4 → XP_011245270.1 transmembrane protein 241 isoform X24