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    Duba Deubiquitinating enzyme A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39302, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Dubaprovided by FlyBase
    Official Full Name
    Deubiquitinating enzyme Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036180
    Locus tag
    Dmel_CG6091
    See related
    AllianceGenome:FB:FBgn0036180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6091; Dmel\CG6091; ped; Q9VTK7
    Summary
    Enables K63-linked deubiquitinase activity. Involved in negative regulation of canonical Wnt signaling pathway and sperm individualization. Is expressed in several structures, including central brain primordium; ganglia; germline cell; gonad; and ventral nerve cord primordium. Orthologous to human OTUD5 (OTU deubiquitinase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Duba in Genome Data Viewer
    Location:
    68C15-68C15; 3-36 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11605436..11609465, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11598536..11602565, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mucin 68Ca

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems. Hofmann K, et al. Trends Biochem Sci, 2001 Jun. PMID 11406394
    2. Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways. Cho JH, et al. Cell Death Differ, 2021 Mar. PMID 33110214, Free PMC Article
    3. The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila. Koerver L, et al. Cell Death Differ, 2016 Dec. PMID 27518434, Free PMC Article
    4. The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila. Farkas A, et al. Sci Rep, 2023 Dec 11. PMID 38081944, Free PMC Article
    5. Prp8 regulates oncogene-induced hyperplastic growth in Drosophila. Fernández-Espartero CH, et al. Development, 2018 Nov 12. PMID 30333215, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DUBA phosphorylation and catalytic activity are crucial in vivo for DUBA function in spermatogenesis.
      Title: The de-ubiquitylating enzyme DUBA is essential for spermatogenesis in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    deubiquitinating enzyme A
    Names
    CG6091-PD
    CG6091-PE
    CG6091-PF
    CG6091-PG
    Duba-PD
    Duba-PE
    Duba-PF
    Duba-PG
    NP_001163417.1
    NP_648482.3
    NP_729723.2
    NP_729724.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11605436..11609465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168465.5 → NP_729723.2  deubiquitinating enzyme A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729723.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQP6, Q95S49, Q9VTK7
      Conserved Domains (1) summary
      cl19932
      Location:224 → 334
      OTU; OTU-like cysteine protease

    2. NM_140225.6 → NP_648482.3  deubiquitinating enzyme A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648482.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQP6, Q95S49, Q9VTK7
      Conserved Domains (1) summary
      cl19932
      Location:224 → 334
      OTU; OTU-like cysteine protease

    3. NM_001169946.2 → NP_001163417.1  deubiquitinating enzyme A, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163417.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIE7, Q95S49
      Conserved Domains (1) summary
      cl19932
      Location:224 → 334
      OTU; OTU-like cysteine protease

    4. NM_168466.4 → NP_729724.2  deubiquitinating enzyme A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729724.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86NP6, Q8IQF9
      Conserved Domains (1) summary
      cl19932
      Location:64 → 174
      OTU; OTU-like cysteine protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIE7 E1JIE7
    Q8IQF9 Q8IQF9
    Q95S49 Q95S49
    Q9VTK7 Q9VTK7

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