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    Rca1 Regulator of cyclin A1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33959, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Rca1provided by FlyBase
    Official Full Name
    Regulator of cyclin A1provided by FlyBase
    Primary source
    FLYBASE:FBgn0017551
    Locus tag
    Dmel_CG10800
    See related
    AllianceGenome:FB:FBgn0017551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    152549_at; CG10800; CLD4; Dmel\CG10800; Emi1; FBXO5; l(2)03300; P3300; rca1; RCA1; S(rux)2A
    Summary
    Enables ubiquitin ligase inhibitor activity. Involved in G1/S transition of mitotic cell cycle. Located in nucleus. Is expressed in several structures, including central brain primordium; embryonic/larval midgut primordium; ganglia; head mesoderm; and larval nervous system. Human ortholog(s) of this gene implicated in spermatogenic failure 64. Orthologous to human FBXO43 (F-box protein 43) and FBXO5 (F-box protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rca1 in Genome Data Viewer
    Location:
    27C1-27C1; 2-23 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6852315..6853866)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6852315..6853866)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44081 Neighboring gene senseless-2 Neighboring gene lethal (2) k09022 Neighboring gene Na[+]/H[+] hydrogen antiporter 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of sleep by cyclin A and its regulator. Rogulja D, et al. Science, 2012 Mar 30. PMID 22461610, Free PMC Article
    2. An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila. Boukhatmi H, et al. Development, 2014 Oct. PMID 25209244
    3. Requirements of cyclin a for mitosis are independent of its subcellular localization. Dienemann A, et al. Curr Biol, 2004 Jun 22. PMID 15203007
    4. Genome-wide analysis reveals a cell cycle-dependent mechanism controlling centromere propagation. Erhardt S, et al. J Cell Biol, 2008 Dec 1. PMID 19047461, Free PMC Article
    5. Degradation of origin recognition complex large subunit by the anaphase-promoting complex in Drosophila. Araki M, et al. EMBO J, 2003 Nov 17. PMID 14609957, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin ligase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
    Inferred from Sequence Model
    more info
    		  
    involved_in negative regulation of meiotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic nuclear division TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISM
    Inferred from Sequence Model
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulator of cyclin A1
    Names
    CG10800-PA
    Rca1-PA
    regulator of cyclin A
    regulator of cyclin A 1
    suppressor of rux 2A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6852315..6853866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057866.3 → NP_477214.1  regulator of cyclin A1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477214.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91666, Q9VM76
      Related
      FBpp0078970
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91666 P91666
    Q9VM76 Q9VM76

    Gene LinkOut

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