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    Ttd14 TRPL translocation defect 14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37119, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ttd14provided by FlyBase
    Official Full Name
    TRPL translocation defect 14provided by FlyBase
    Primary source
    FLYBASE:FBgn0284257
    Locus tag
    Dmel_CG30118
    See related
    AllianceGenome:FB:FBgn0284257
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16859; CG30118; CG5544; Dmel\CG30118; l(2)08770; l(2)k04808; ttd14; TTD14
    Summary
    Enables GTP binding activity; phosphatidic acid binding activity; and phosphatidylinositol binding activity. Involved in cellular response to light stimulus; photoreceptor cell maintenance; and positive regulation of intracellular protein transport. Located in cytosol. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; endoderm anlage; gut section; and larval muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Ttd14 in Genome Data Viewer
    Location:
    55C9-55C9; 2-85 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18430315..18440475, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14317820..14327980, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene immune deficiency Neighboring gene Dodeca-satellite-binding protein 1 Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class O Neighboring gene scruin like at the midline Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Neighboring gene uncharacterized protein Neighboring gene Pre-RNA processing factor 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells. Cerny AC, et al. PLoS Genet, 2015 Oct. PMID 26509977, Free PMC Article
    2. Dissection of Complex, Fitness-Related Traits in Multiple Drosophila Mapping Populations Offers Insight into the Genetic Control of Stress Resistance. Everman ER, et al. Genetics, 2019 Apr. PMID 30760490, Free PMC Article
    3. Membrane protein trafficking in Drosophila photoreceptor cells. Schopf K, et al. Eur J Cell Biol, 2017 Aug. PMID 27964885
    4. Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover. Huang S, et al. PLoS Biol, 2013 Nov. PMID 24302888, Free PMC Article
    5. Identification and characterization of genes involved in embryonic crystal cell formation during Drosophila hematopoiesis. Milchanowski AB, et al. Genetics, 2004 Sep. PMID 15454546, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in photoreceptor cell maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TRPL translocation defect 14
    Names
    CG30118-PA
    CG30118-PB
    CG30118-PC
    Ttd14-PA
    Ttd14-PB
    Ttd14-PC
    lethal (2) 08770

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18430315..18440475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103896.2 → NP_001097366.1  TRPL translocation defect 14, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097366.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYI2
      Conserved Domains (2) summary
      pfam13521
      Location:68 → 293
      AAA_28; AAA domain
      cl11964
      Location:323 → 481
      CYTH-like_Pase; CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases

    2. NM_001103895.2 → NP_001097365.1  TRPL translocation defect 14, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097365.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K556
      Conserved Domains (2) summary
      pfam13521
      Location:68 → 249
      AAA_28; AAA domain
      cl11964
      Location:279 → 437
      CYTH-like_Pase; CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases

    3. NM_137489.4 → NP_611333.1  TRPL translocation defect 14, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611333.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYI1, Q7K556
      Related
      FBpp0085903
      Conserved Domains (2) summary
      pfam13521
      Location:68 → 249
      AAA_28; AAA domain
      cl11964
      Location:279 → 437
      CYTH-like_Pase; CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DYI2 A8DYI2
    Q7K556.1 Q7K556

    Gene LinkOut

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