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    CG1774 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43722, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG1774provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039856
    Locus tag
    Dmel_CG1774
    See related
    AllianceGenome:FB:FBgn0039856
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG1774
    Summary
    Predicted to enable acetyl-CoA hydrolase activity and fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Orthologous to human ACOT9 (acyl-CoA thioesterase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG1774 in Genome Data Viewer
    Location:
    100C7-100C7; 3-102 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31592803..31594719)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27418525..27420441)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45190 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L6 Neighboring gene Cyclin G Neighboring gene Medea

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CoA protects against the deleterious effects of caloric overload in Drosophila. Palanker Musselman L, et al. J Lipid Res, 2016 Mar. PMID 26805007, Free PMC Article
    2. The Toll pathway underlies host sexual dimorphism in resistance to both Gram-negative and Gram-positive bacteria in mated Drosophila. Duneau DF, et al. BMC Biol, 2017 Dec 21. PMID 29268741, Free PMC Article
    3. Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Juhász G, et al. Cell Death Differ, 2007 Jun. PMID 17363962, Free PMC Article
    4. Flexible origin of hydrocarbon/pheromone precursors in Drosophila melanogaster. Wicker-Thomas C, et al. J Lipid Res, 2015 Nov. PMID 26353752, Free PMC Article
    5. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. Zinke I, et al. EMBO J, 2002 Nov 15. PMID 12426388, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetyl-CoA hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acyl-CoA metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG1774-PA
    CG1774-PB
    NP_001287623.1
    NP_651875.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31592803..31594719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143618.3 → NP_651875.1  uncharacterized protein Dmel_CG1774, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651875.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9W4
      Related
      FBpp0085159
      Conserved Domains (1) summary
      cd03442
      Location:107 → 241
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

    2. NM_001300694.1 → NP_001287623.1  uncharacterized protein Dmel_CG1774, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287623.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9W4
      Conserved Domains (1) summary
      cd03442
      Location:107 → 241
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V9W4 Q9V9W4

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