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    Oatp74D Organic anion transporting polypeptide 74D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39954, updated on 17-Dec-2024

    Summary

    Official Symbol
    Oatp74Dprovided by FlyBase
    Official Full Name
    Organic anion transporting polypeptide 74Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036732
    Locus tag
    Dmel_CG7571
    See related
    AllianceGenome:FB:FBgn0036732
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7571; Dmel\CG7571; EcI; oatp 74D
    Summary
    Predicted to enable sodium-independent organic anion transmembrane transporter activity. Involved in ecdysone receptor signaling pathway and larval development. Located in intracellular membrane-bounded organelle and plasma membrane. Is expressed in several structures, including adult head; anterior endoderm anlage; foregut anlage in statu nascendi; mesectoderm; and midline primordium. Orthologous to human SLCO2B1 (solute carrier organic anion transporter family member 2B1) and SLCO3A1 (solute carrier organic anion transporter family member 3A1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Oatp74D in Genome Data Viewer
    Location:
    74D1-74D2; 3-45 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17487118..17511693)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17480218..17504793)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene quijote Neighboring gene elevated during infection Neighboring gene U4-U6 small nuclear riboprotein factor 60K Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in ecdysone receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in larval development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in organic anion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    organic anion transporting polypeptide 74D
    Names
    CG7571-PA
    CG7571-PC
    CG7571-PD
    CG7571-PE
    Oatp74D-PA
    Oatp74D-PC
    Oatp74D-PD
    Oatp74D-PE
    ecdysone importer

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17487118..17511693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169989.2NP_001163460.1  organic anion transporting polypeptide 74D, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163460.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVH9
      Conserved Domains (1) summary
      pfam03137
      Location:175754
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    2. NM_140732.3NP_648989.1  organic anion transporting polypeptide 74D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648989.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVH9
      Related
      FBpp0074939
      Conserved Domains (1) summary
      pfam03137
      Location:175754
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    3. NM_001300167.1NP_001287096.1  organic anion transporting polypeptide 74D, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287096.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVH9
      Conserved Domains (1) summary
      pfam03137
      Location:175754
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    4. NM_001300166.1NP_001287095.1  organic anion transporting polypeptide 74D, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287095.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVH9
      Conserved Domains (1) summary
      pfam03137
      Location:175754
      OATP; Organic Anion Transporter Polypeptide (OATP) family