NetB Netrin-B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: NetBprovided by FlyBase
Official Full Name: Netrin-Bprovided by FlyBase
Primary source: FLYBASE:FBgn0015774
Locus tag: Dmel_CG10521
See related: AllianceGenome:FB:FBgn0015774
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10521; CG15021; CT29512; Dmel\CG10521; net; netB; NETB; netrin; netrin B; NetrinB
Summary: Involved in several processes, including neurogenesis; regulation of photoreceptor cell axon guidance; and salivary gland boundary specification. Located in axonal growth cone; neuronal cell body; and perinuclear region of cytoplasm. Is expressed in several structures, including ISN innervated muscle cell of A1-7; embryonic cardioblast; imaginal disc primordium; optic lobe intrinsic columnar neurons; and somatic precursor cell. Human ortholog(s) of this gene implicated in congenital mirror movement disorder. Orthologous to human NTN1 (netrin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 12F2-12F3; 1-49 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (14686038..14749376, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (14580071..14643409, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oncogenic stress-induced Netrin is a humoral signaling molecule that reprograms systemic metabolism in Drosophila.
Title: Oncogenic stress-induced Netrin is a humoral signaling molecule that reprograms systemic metabolism in Drosophila.
Asymmetric activity of NetrinB controls laterality of the Drosophila brain.
Title: Asymmetric activity of NetrinB controls laterality of the Drosophila brain.
These results indicate a critical role for Netrin B in mushroom body lobe extension.
Title: Drosophila Netrin-B controls mushroom body axon extension and regulates courtship-associated learning and memory of a Drosophila fragile X syndrome model.
mutation of mushroom body defect (mud) dramatically enhances the phenotype of Netrin or frazzled mutants, resulting in many more axons failing to cross the midline, although mutations in mud alone have little effect.
Title: Mushroom body defect is required in parallel to Netrin for midline axon guidance in Drosophila.
Contact-mediated cell adhesion via Fmi acts in addition to the Net/Fra guidance system during axon pathfinding across the midline, underlining the importance of PCP molecules during vertebrates and invertebrates midline development.
Title: Flamingo, a seven-pass transmembrane cadherin, cooperates with Netrin/Frazzled in Drosophila midline guidance.
adult Drosophila lacking both netrin genes, NetA and NetB, have fertility defects in both sexes together with an inability to fly and reduced viability.
Title: Control of male and female fertility by the netrin axon guidance genes.
These data are the first to show that Netrin and Frazzled regulate the placement of gap junctions presynaptically at a synapse.
Title: Netrin and Frazzled regulate presynaptic gap junctions at a Drosophila giant synapse.
Data find that Abl interacts both physically and genetically with the Netrin receptor Frazzled, and that disrupting this interaction prevents Abl from promoting midline axon crossing.
Title: Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits.
Netrin-B is specifically localized in photoreceptor axons owing to axonal release by lamina neurons L3 and capture by target neuron-associated Frazzled.
Title: Localized netrins act as positional cues to control layer-specific targeting of photoreceptor axons in Drosophila.
Dscam1 functions to counter Drosophila sensory neuron dendritic targeting signals provided by secreted Netrin-B and Frazzled, a netrin receptor. Loss of Dscam1 function resulted in aberrant dendrite accumulation at a Netrin-B-expressing target.
Title: Dscam1-mediated self-avoidance counters netrin-dependent targeting of dendrites in Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in compound eye development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite development	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland boundary specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic target attraction	TAS Traceable Author Statement more info	PubMed
involved_in synaptic target recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axonal growth cone	IGI Inferred from Genetic Interaction more info	PubMed
located_in axonal growth cone	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Netrin-B

Names: CG10521-PA; CG10521-PB; CG10521-PC; CG10521-PD; CG10521-PE; CG10521-PF; CG10521-PG; D-netrin; D-netrin-B; NetB-PA; NetB-PB; NetB-PC; NetB-PD; NetB-PE; NetB-PF; NetB-PG; netrin; netrin B; netrin-B; netrinB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

14686038..14749376 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169284.2 → NP_001162755.1 Netrin-B, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162755.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24568, Q9VY23

UniProtKB/TrEMBL

E1JJP7

Conserved Domains (3) summary

smart00136
Location:37 → 261

LamNT; Laminin N-terminal domain (domain VI)

cd00055
Location:560 → 608

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:661 → 791

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
NM_001258740.2 → NP_001245669.1 Netrin-B, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245669.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24568, Q9VY23

UniProtKB/TrEMBL

E1JJP7

Conserved Domains (3) summary

smart00136
Location:37 → 261

LamNT; Laminin N-terminal domain (domain VI)

cd00055
Location:560 → 608

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:661 → 791

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
NM_001169283.2 → NP_001162754.1 Netrin-B, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162754.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24568, Q9VY23

UniProtKB/TrEMBL

E1JJP7

Conserved Domains (3) summary

smart00136
Location:37 → 261

LamNT; Laminin N-terminal domain (domain VI)

cd00055
Location:560 → 608

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:661 → 791

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
NM_001258739.2 → NP_001245668.1 Netrin-B, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245668.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24568, Q9VY23

UniProtKB/TrEMBL

E1JJP7

Conserved Domains (3) summary

smart00136
Location:37 → 261

LamNT; Laminin N-terminal domain (domain VI)

cd00055
Location:560 → 608

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:661 → 791

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
NM_078600.4 → NP_511155.1 Netrin-B, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511155.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24568, Q9VY23

UniProtKB/TrEMBL

E1JJP7

Related

FBpp0073757

Conserved Domains (3) summary

smart00136
Location:37 → 261

LamNT; Laminin N-terminal domain (domain VI)

cd00055
Location:560 → 608

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:661 → 791

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
NM_001272617.1 → NP_001259546.1 Netrin-B, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259546.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PH47

Conserved Domains (3) summary

smart00136
Location:29 → 253

LamNT; Laminin N-terminal domain (domain VI)

cd00055
Location:552 → 600

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:653 → 783

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
NM_001169282.1 → NP_001162753.1 Netrin-B, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162753.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24568, Q9VY23

UniProtKB/TrEMBL

E1JJP7

Conserved Domains (3) summary

smart00136
Location:37 → 261

LamNT; Laminin N-terminal domain (domain VI)

cd00055
Location:560 → 608

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd03579
Location:661 → 791

NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...