rut rutabaga [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rutprovided by FlyBase
Official Full Name: rutabagaprovided by FlyBase
Primary source: FLYBASE:FBgn0003301
Locus tag: Dmel_CG9533
See related: AllianceGenome:FB:FBgn0003301
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AC; Ac12F; CG9533; dADCY1; Dmel\CG9533; EP1603; Rut; RUT; Rut-AC
Summary: Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in several processes, including behavioral response to ethanol; determination of adult lifespan; and learning or memory. Located in membrane. Is expressed in several structures, including adult brain; ganglia; mushroom body; synaptic neuropil domain; and synaptic neuropil subdomain. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 44. Orthologous to human ADCY1 (adenylate cyclase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 12F4-12F5; 1-49 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (14787478..14826073, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (14681511..14720106, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sleep restores place learning to the adenylyl cyclase mutant rutabaga.
Title: Sleep restores place learning to the adenylyl cyclase mutant rutabaga.
Mutations in chico reduce expression of the rutabaga-type adenylyl cyclase (rut), leading to decreased cAMP synthesis in the mushroom bodies.
Title: Learning defects in Drosophila growth restricted chico mutants are caused by attenuated adenylyl cyclase activity.
Analyzing acquisition dynamics in Drosophila memory mutants reveals that rutabaga (rut)-dependent cyclic AMP signals couple in a divergent fashion for support of different memory components.
Title: AKAPS act in a two-step mechanism of memory acquisition.
Rutabaga-dependent ethanol self-administration may function through alcohol's positive reinforcement of feeding behavior in Drosophila.
Title: The propensity for consuming ethanol in Drosophila requires rutabaga adenylyl cyclase expression within mushroom body neurons.
The results of this study supported the idea that GABA-rutabaga-dependent inhibition of gustatory interneurons is critical for PER habituation.
Title: Gustatory habituation in Drosophila relies on rutabaga (adenylate cyclase)-dependent plasticity of GABAergic inhibitory neurons.
Our results suggest that Rutabaga acts as a coincidence detector and demonstrate the existence of subcellular domains of PKA activity that could underlie the functional specialization of mushroom body lobes in aversive and appetitive learning.
Title: PKA dynamics in a Drosophila learning center: coincidence detection by rutabaga adenylyl cyclase and spatial regulation by dunce phosphodiesterase.
a novel role of rut in homeostatic plasticity
Title: Pre- and post-synaptic mechanisms of synaptic strength homeostasis revealed by slowpoke and shaker K+ channel mutations in Drosophila.
Learning scores at the second session were higher with shorter delays between two learning sessions and retrograde amnesia could decrease this memory score. rutabaga mutants showed learning deficits in experiments testing groups of flies.
Title: Further characterization of an aversive learning task in Drosophila melanogaster: intensity of the stimulus, relearning, and use of rutabaga mutants.
flies responding to visual novelty revealed attention-like processes with stereotypical temporal properties; these processes were modulated by genes involved in short-term memory formation, namely dunce and rutabaga
Title: Attention-like processes in Drosophila require short-term memory genes.
transient expression of the rutabaga-encoded adenylyl cyclase in the mushroom bodies of the adult brain was necessary and sufficient to rescue the rutabaga memory deficit and demonstrates an acute role for rutabaga in memory formation in these neurons
Title: Spatiotemporal rescue of memory dysfunction in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c14815773-14815571 mobile_element_type = transposon:INE-1{}3042
Loc: c14823965-14818820 mobile_element_type = transposon:copia{}131

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables calcium- and calmodulin-responsive adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium- and calmodulin-responsive adenylate cyclase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anesthesia-resistant memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in associative learning	IDA Inferred from Direct Assay more info	PubMed
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in conditioned taste aversion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in courtship behavior	TAS Traceable Author Statement more info	PubMed
involved_in cyclic nucleotide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mating behavior	TAS Traceable Author Statement more info	PubMed
involved_in medium-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in molting cycle, chitin-based cuticle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	TAS Traceable Author Statement more info	PubMed
involved_in regulation of olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rutabaga

Names: CG9533-PA; CG9533-PB; CG9533-PC; CG9533-PD; CG9533-PE; CG9533-PF; CG9533-PG; RUTABAGA; adenylyl cyclase; rut-PA; rut-PB; rut-PC; rut-PD; rut-PE; rut-PF; rut-PG; rutabage

NP_001245672.1

EC 4.6.-.-

EC 4.6.1.1

NP_001259548.1

EC 4.6.-.-

EC 4.6.1.1

NP_001259549.1

EC 4.6.-.-

EC 4.6.1.1

NP_001259550.1

EC 4.6.-.-

EC 4.6.1.1

NP_001259551.1

EC 4.6.-.-

EC 4.6.1.1

NP_001285246.1

EC 4.6.-.-

EC 4.6.1.1

NP_511156.2

EC 4.6.-.-

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

14787478..14826073 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258743.3 → NP_001245672.1 rutabaga, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245672.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NF51

Conserved Domains (6) summary

smart00818
Location:1242 → 1373

Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth

smart00044
Location:230 → 425

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:266 → 438

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:561 → 619

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:17 → 255

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

cl00456
Location:665 → 816

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
NM_001272619.2 → NP_001259548.1 rutabaga, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259548.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PHL3

Conserved Domains (5) summary

smart00044
Location:230 → 425

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:266 → 438

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:561 → 619

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:17 → 255

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

cl00456
Location:665 → 816

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
NM_001298317.1 → NP_001285246.1 rutabaga, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285246.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PJN1

Conserved Domains (5) summary

smart00044
Location:230 → 425

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:266 → 438

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:561 → 619

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:17 → 255

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

cl00456
Location:665 → 816

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
NM_078601.4 → NP_511156.2 rutabaga, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511156.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P32870, Q9TWA7, Q9VY17

Related

FBpp0073809

Conserved Domains (5) summary

smart00044
Location:230 → 425

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:266 → 438

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:624 → 696

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:17 → 255

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

cl00456
Location:742 → 893

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
NM_001272621.2 → NP_001259550.1 rutabaga, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259550.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEL4

Conserved Domains (5) summary

smart00044
Location:230 → 425

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:266 → 438

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:561 → 619

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:17 → 255

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

cl00456
Location:665 → 816

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
NM_001272622.2 → NP_001259551.1 rutabaga, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259551.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PH52

Conserved Domains (5) summary

smart00044
Location:230 → 425

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:266 → 438

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:561 → 619

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:17 → 255

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

cl00456
Location:665 → 816

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
NM_001272620.2 → NP_001259549.1 rutabaga, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259549.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PJN1

Conserved Domains (5) summary

smart00044
Location:230 → 425

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:266 → 438

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:561 → 619

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:17 → 255

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

cl00456
Location:665 → 816

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain