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    PolZ2 DNA polymerase zeta subunit 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40677, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PolZ2provided by FlyBase
    Official Full Name
    DNA polymerase zeta subunit 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037345
    Locus tag
    Dmel_CG2948
    See related
    AllianceGenome:FB:FBgn0037345
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2948; Dmel\CG2948; DmREV7; mad2B; rev7; Rev7
    Summary
    Part of zeta DNA polymerase complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group V. Orthologous to human MAD2L2 (mitotic arrest deficient 2 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PolZ2 in Genome Data Viewer
    Location:
    83B4-83B4; 3-47.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5588873..5589703)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1414595..1415425)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Collapsin Response Mediator Protein Neighboring gene small Cajal body-specific RNA : MeU4:25F-C137 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene noisette Neighboring gene Vacuolar H[+]-ATPase 26kD subunit Neighboring gene krasavietz

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila DNA polymerase zeta interacts with recombination repair protein 1, the Drosophila homologue of human abasic endonuclease 1. Takeuchi R, et al. J Biol Chem, 2006 Apr 28. PMID 16507570
    2. Comparative analysis of in vivo interactions between Rev1 protein and other Y-family DNA polymerases in animals and yeasts. Kosarek JN, et al. DNA Repair (Amst), 2008 Mar 1. PMID 18242152, Free PMC Article
    3. Flies without a spindle checkpoint. Buffin E, et al. Nat Cell Biol, 2007 May. PMID 17417628
    4. Purification of Drosophila DNA polymerase zeta by REV1 protein-affinity chromatography. Takeuchi R, et al. Biochem J, 2004 Sep 1. PMID 15175013, Free PMC Article
    5. The DNA polymerases of Drosophila melanogaster. Marygold SJ, et al. Fly (Austin), 2020 Mar-Dec. PMID 31933406, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of zeta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of zeta DNA polymerase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase zeta subunit 2
    Names
    CG2948-PA
    DNA polymerase zeta Rev7 subunit
    PolZ2-PA
    rev7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5588873..5589703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141298.2 → NP_649555.1  DNA polymerase zeta subunit 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649555.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LF70, Q9VNE1
      Related
      FBpp0078348
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNE1.1 Q9VNE1

    Gene LinkOut

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