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    stv starvin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39518, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stvprovided by FlyBase
    Official Full Name
    starvinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086708
    Locus tag
    Dmel_CG32130
    See related
    AllianceGenome:FB:FBgn0086708
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10745; CG14108; cg32130; CG32130; dBAG3; Dmel\CG32130; GH04349; l(3)00543; Stv
    Summary
    Enables heat shock protein binding activity. Involved in positive regulation of protein lipidation. Located in Z disc. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic dorsal epidermis; embryonic epipharynx; and gut section. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1HH and myofibrillar myopathy 6. Orthologous to several human genes including BAG4 (BAG cochaperone 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See stv in Genome Data Viewer
    Location:
    70B2-70B2; 3-40 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13477541..13483515)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13470641..13476615)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Actin binding protein 1 Neighboring gene Tondu-domain-containing Growth Inhibitor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spatial analysis of gene regulation reveals new insights into the molecular basis of upper thermal limits. Telonis-Scott M, et al. Mol Ecol, 2014 Dec. PMID 25401770
    2. PINK1 and Parkin Ameliorate the Loss of Motor Activity and Mitochondrial Dysfunction Induced by Peripheral Neuropathy-Associated HSPB8 Mutants in Drosophila Models. Kang KH, et al. Biomedicines, 2023 Mar 9. PMID 36979812, Free PMC Article
    3. Gene and protein expression of Drosophila Starvin during cold stress and recovery from chill coma. Colinet H, et al. Insect Biochem Mol Biol, 2010 May. PMID 20303406
    4. Temporal specific coevolution of Hsp70 and co-chaperone stv expression in Drosophila melanogaster under selection for heat tolerance. Telonis-Scott M, et al. J Therm Biol, 2021 Dec. PMID 34863477
    5. Drosophila p38 MAPK interacts with BAG-3/starvin to regulate age-dependent protein homeostasis. Ryan SM, et al. Aging Cell, 2021 Nov. PMID 34674371, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Temporal specific coevolution of Hsp70 and co-chaperone stv expression in Drosophila melanogaster under selection for heat tolerance.
      Title: Temporal specific coevolution of Hsp70 and co-chaperone stv expression in Drosophila melanogaster under selection for heat tolerance.
    2. Stv expression is part of a stress-induced program in D. melanogaster. It probably acts as a co-chaperone modulating the activity of Hsp70 chaperone machinery during recovery from cold stress.
      Title: Gene and protein expression of Drosophila Starvin during cold stress and recovery from chill coma.
    3. reveal the importance of chaperone (starvin)-assisted degradation for the preservation of cellular structures and identify muscle as a tissue that highly relies on an intact proteostasis network, thereby shedding light on diverse myopathies and aging
      Title: Chaperone-assisted selective autophagy is essential for muscle maintenance.
    4. Drosophila starvin encodes a tissue-specific BAG-domain protein required for larval food uptake.
      Title: Drosophila starvin encodes a tissue-specific BAG-domain protein required for larval food uptake.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein lipidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    starvin
    Names
    CG32130-PA
    CG32130-PB
    CG32130-PC
    CG32130-PD
    CG32130-PE
    CG32130-PF
    CG32130-PG
    Dm-Starvin
    lethal (3) 00543
    starving
    stv-PA
    stv-PB
    stv-PC
    stv-PD
    stv-PE
    stv-PF
    stv-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13477541..13483515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274875.1 → NP_001261804.1  starvin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261804.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCD9
      Conserved Domains (1) summary
      pfam02179
      Location:445 → 516
      BAG; BAG domain

    2. NM_001104130.2 → NP_001097600.1  starvin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNS4
      Conserved Domains (1) summary
      pfam02179
      Location:470 → 541
      BAG; BAG domain

    3. NM_168551.2 → NP_729910.1  starvin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729910.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TF3, Q9VU81
      Related
      FBpp0075548
      Conserved Domains (1) summary
      pfam02179
      Location:444 → 515
      BAG; BAG domain

    4. NM_001274876.1 → NP_001261805.1  starvin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU83
      Conserved Domains (1) summary
      pfam02179
      Location:351 → 422
      BAG; BAG domain

    5. NM_168553.2 → NP_729912.1  starvin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729912.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU83
      Related
      FBpp0075549
      Conserved Domains (1) summary
      pfam02179
      Location:351 → 422
      BAG; BAG domain

    6. NM_168552.2 → NP_729911.1  starvin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729911.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU82
      Related
      FBpp0075550
      Conserved Domains (1) summary
      pfam02179
      Location:377 → 448
      BAG; BAG domain

    7. NM_168554.2 → NP_729913.1  starvin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729913.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU83
      Related
      FBpp0075551
      Conserved Domains (1) summary
      pfam02179
      Location:351 → 422
      BAG; BAG domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNS4 A8JNS4
    M9PCD9 M9PCD9
    Q9VU81 Q9VU81
    Q9VU82 Q9VU82
    Q9VU83 Q9VU83

    Gene LinkOut

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