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    lky leaky [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33006, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lkyprovided by FlyBase
    Official Full Name
    leakyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031082
    Locus tag
    Dmel_CG17003
    See related
    AllianceGenome:FB:FBgn0031082
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17003; Dmel\CG17003
    Summary
    Enables tubulin N-acetyltransferase activity. Predicted to be involved in microtubule cytoskeleton organization. Located in fusome. Orthologous to human ATAT1 (alpha tubulin acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lky in Genome Data Viewer
    Location:
    19A4-19A4; 1-64 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20000968..20002096, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19895001..19896129, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Neprilysin 3 Neighboring gene Dopamine 2-like receptor Neighboring gene transfer RNA:Proline-CGG 1-1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATAT1-enriched vesicles promote microtubule acetylation via axonal transport. Even A, et al. Sci Adv, 2019 Dec. PMID 31897425, Free PMC Article
    2. Circuit Analysis of a Drosophila Dopamine Type 2 Receptor That Supports Anesthesia-Resistant Memory. Scholz-Kornehl S, et al. J Neurosci, 2016 Jul 27. PMID 27466338, Free PMC Article
    3. Drosophila CG17003/leaky (lky) is required for microtubule acetylation in early germ cells in Drosophila ovary. Antel M, et al. PLoS One, 2022. PMID 36342916, Free PMC Article
    4. Natural genetic variation in a dopamine receptor is associated with variation in female fertility in Drosophila melanogaster. Lyman RF, et al. Proc Biol Sci, 2023 Apr 12. PMID 37040806, Free PMC Article
    5. Microtubule Acetylation Is Required for Mechanosensation in Drosophila. Yan C, et al. Cell Rep, 2018 Oct 23. PMID 30355484, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tubulin N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin N-acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in alpha-tubulin acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in fusome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leaky
    Names
    CG17003-PA
    lky-PA
    NP_608365.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      20000968..20002096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134521.3 → NP_608365.1  leaky [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608365.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T8W1, Q9W5X9
      Related
      FBpp0070034
      Conserved Domains (1) summary
      pfam05301
      Location:84 → 194
      Mec-17; Touch receptor neuron protein Mec-17
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W5X9.1 Q9W5X9

    Gene LinkOut

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