U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Hsp68 Heat shock protein 68 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42852, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Hsp68provided by FlyBase
    Official Full Name
    Heat shock protein 68provided by FlyBase
    Primary source
    FLYBASE:FBgn0001230
    Locus tag
    Dmel_CG5436
    See related
    AllianceGenome:FB:FBgn0001230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    68; CG5436; Dmel\CG5436; DmHsp68; Hsp-68; hsp68; HSP68; HSP68_DROME; HSP70cA7
    Summary
    Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Involved in determination of adult lifespan and response to starvation. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in adult head and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Hsp68 in Genome Data Viewer
    Location:
    95D11-95D11; 3-82 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24055080..24057310, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19880802..19883032, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44097 Neighboring gene Autophagy-related 6 Neighboring gene Phosphatidylserine decarboxylase Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes 1 Neighboring gene eukaryotic translation initiation factor 4E homologous protein Neighboring gene Syntaxin 1A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The hsp70 locus of Drosophila auraria (montium subgroup) is single and contains copies in a conserved arrangement. Konstantopoulou I, et al. Chromosoma, 1998 Dec. PMID 9933411
    2. Frequency and voltage dependence of the dielectrophoretic trapping of short lengths of DNA and dCTP in a nanopipette. Ying L, et al. Biophys J, 2004 Feb. PMID 14747337, Free PMC Article
    3. The developmentally-regulated Drosophila gene rox8 encodes an RRM-type RNA binding protein structurally related to human TIA-1-type nucleolysins. Brand S, et al. Nucleic Acids Res, 1993 Aug 11. PMID 8396236, Free PMC Article
    4. Response of two heat shock genes to selection for knockdown heat resistance in Drosophila melanogaster. McColl G, et al. Genetics, 1996 Aug. PMID 8844150, Free PMC Article
    5. Tissue dissociation for single-cell and single-nuclei RNA sequencing for low amounts of input material. Wiegleb G, et al. Front Zool, 2022 Nov 12. PMID 36371195, Free PMC Article

    See all (185) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    heat shock protein 68
    Names
    70 kDa heat shock protein, cytosolic A 7
    CG5436-PA
    Hsp 68
    Hsp68-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24055080..24057310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079750.4 → NP_524474.1  heat shock protein 68 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524474.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O97125
      Related
      FBpp0083974
      Conserved Domains (2) summary
      cd10233
      Location:3 → 379
      HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
      PTZ00009
      Location:2 → 635
      PTZ00009; heat shock 70 kDa protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97125.1 O97125

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous