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    ea easter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41858, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eaprovided by FlyBase
    Official Full Name
    easterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000533
    Locus tag
    Dmel_CG4920
    See related
    AllianceGenome:FB:FBgn0000533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-SP24; CG4920; cSP24; Dmel\CG4920; Ea; EA; SP24
    Summary
    Enables serine-type endopeptidase activity. Involved in several processes, including Toll receptor ligand protein activation cascade; dorsal/ventral axis specification; and ventral furrow formation. Located in extracellular space and perivitelline space. Is expressed in organism and ovary. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    88F1-88F1; 3-57 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15328729..15330408)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11154451..11156130)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ENL/AF9-related Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene FK506-binding protein 39kD Neighboring gene Cytoplasmic FMR1 interacting protein Neighboring gene N-acetylglucosamine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of easter, an apparent serine protease, in organizing the dorsal-ventral pattern of the Drosophila embryo. Chasan R, et al. Cell, 1989 Feb 10. PMID 2492450
    2. Dominant and recessive alleles of the Drosophila easter gene are point mutations at conserved sites in the serine protease catalytic domain. Jin YS, et al. Cell, 1990 Mar 9. PMID 2107028
    3. A common domain within the proenzyme regions of the Drosophila snake and easter proteins and Tachypleus proclotting enzyme defines a new subfamily of serine proteases. Smith CL, et al. Protein Sci, 1992 Sep. PMID 1304399, Free PMC Article
    4. In vitro maturation of Drosophila melanogaster Spätzle protein with refolded Easter reveals a novel cleavage site within the prodomain. Ursel C, et al. Biol Chem, 2013 Aug. PMID 23729565
    5. Mutational analysis of the Drosophila snake protease: an essential role for domains within the proenzyme polypeptide chain. Smith C, et al. Genetics, 1994 Apr. PMID 8013912, Free PMC Article

    See all (172) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The study reports the expression and refolding of Easter, and show that the renatured enzyme performs the activation cleavage of two spatzle isoforms.
      Title: In vitro maturation of Drosophila melanogaster Spätzle protein with refolded Easter reveals a novel cleavage site within the prodomain.
    2. observation suggests a mechanism in which the sulfated target of Pipe promotes a productive interaction between Snake and Easter, perhaps by facilitating conformational changes in a complex containing the two proteins
      Title: Pipe-dependent ventral processing of Easter by Snake is the defining step in Drosophila embryo DV axis formation.
    3. Easter plays a role in generating the wild-type shape of the Dorsal gradient in the developing Drosophila embryo
      Title: Regulation of Easter activity is required for shaping the Dorsal gradient in the Drosophila embryo.
    4. provision of three-dimensional model and role of cation binding sites in embryo patterning
      Title: Three-dimensional models of proteases involved in patterning of the Drosophila Embryo. Crucial role of predicted cation binding sites.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Toll receptor ligand protein activation cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Toll receptor ligand protein activation cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Toll receptor ligand protein activation cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral axis specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maternal specification of dorsal/ventral axis, oocyte, germ-line encoded TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in ventral furrow formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perivitelline space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    easter
    Names
    CG4920-PA
    CG4920-PB
    ea-PA
    ea-PB
    NP_001262597.1
    NP_524362.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15328729..15330408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275668.1 → NP_001262597.1  easter, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262597.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGQ4
      Conserved Domains (2) summary
      smart00020
      Location:3 → 255
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:3 → 258
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_079638.3 → NP_524362.2  easter, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524362.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P13582, Q9VF90
      Related
      FBpp0082539
      Conserved Domains (3) summary
      smart00020
      Location:127 → 386
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:128 → 389
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam12032
      Location:37 → 89
      CLIP; Regulatory CLIP domain of proteinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGQ4 A0A0B4KGQ4
    P13582.3 P13582

    Gene LinkOut

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